Human TAX1BP3 Recombinant Protein (RPPB4911)
- SKU:
- RPPB4911
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14907
Description
| Product Name: | Human TAX1BP3 Recombinant Protein |
| Product Code: | RPPB4911 |
| Size: | 25µg |
| Species: | Human |
| Target: | TAX1BP3 |
| Synonyms: | Tax1 (human T-cell leukemia virus type I) binding protein 3, TIP-1, Glutaminase-interacting protein 3, Tax interaction protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TAX1BP3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 0.1M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS |
TAX1BP3 holds one PDZ domain, which uses for interactions with other proteins like the interaction with the C-terminus of Rhotekin that facilitates Rho-mediated activation of the FOS serum response element. In addition, PDZ domain interacts with beta-catenin to inhibit the transcriptional activity of beta-catenin. TAX1BP3 exists in several cell lines, such as HeLa, and is expressed in small quantities in peripheral blood leukocytes.
TAX1BP3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (1-124 a.a.) and having a molecular mass of 15.8kDa.TAX1BP3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TAX1BP3: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Adaptor/scaffold Chromosomal Location of Human Ortholog: 17p13 Cellular Component: cytosol Molecular Function:protein binding; protein C-terminus binding Biological Process: negative regulation of Wnt receptor signaling pathway; Rho protein signal transduction |
| UniProt Code: | O14907 |
| NCBI GenInfo Identifier: | 74739481 |
| NCBI Gene ID: | 30851 |
| NCBI Accession: | O14907.2 |
| UniProt Secondary Accession: | O14907,Q7LCQ4, B2RD53, D3DTJ6, |
| UniProt Related Accession: | O14907 |
| Molecular Weight: | 13,735 Da |
| NCBI Full Name: | Tax1-binding protein 3 |
| NCBI Synonym Full Names: | Tax1 binding protein 3 |
| NCBI Official Symbol: | TAX1BP3�� |
| NCBI Official Synonym Symbols: | TIP1; TIP-1�� |
| NCBI Protein Information: | tax1-binding protein 3 |
| UniProt Protein Name: | Tax1-binding protein 3 |
| UniProt Synonym Protein Names: | Glutaminase-interacting protein 3; Tax interaction protein 1; TIP-1; Tax-interacting protein 1 |
| UniProt Gene Name: | TAX1BP3�� |
| UniProt Entry Name: | TX1B3_HUMAN |
