| UniProt Protein Function: | ZRANB1: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. Belongs to the peptidase C64 family.Protein type: Protease; Ligase; EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 10q26.13Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: protein binding; ubiquitin-specific protease activityBiological Process: cell migration; cytoskeleton organization and biogenesis; positive regulation of Wnt receptor signaling pathway; regulation of cell morphogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9UGI0 |
| NCBI GenInfo Identifier: | 212276487 |
| NCBI Gene ID: | 54764 |
| NCBI Accession: | Q9UGI0.2 |
| UniProt Secondary Accession: | Q9UGI0,Q5SQP6, Q69YK3, B4DZ98, D3DRF4 |
| UniProt Related Accession: | Q9UGI0 |
| Molecular Weight: | 80,967 Da |
| NCBI Full Name: | Ubiquitin thioesterase ZRANB1 |
| NCBI Synonym Full Names: | zinc finger RANBP2-type containing 1 |
| NCBI Official Symbol: | ZRANB1 |
| NCBI Official Synonym Symbols: | TRABID |
| NCBI Protein Information: | ubiquitin thioesterase ZRANB1 |
| UniProt Protein Name: | Ubiquitin thioesterase ZRANB1 |
| UniProt Synonym Protein Names: | TRAF-binding domain-containing protein; hTrabid; Zinc finger Ran-binding domain-containing protein 1 |
| Protein Family: | Ubiquitin thioesterase |
| UniProt Gene Name: | ZRANB1 |
| UniProt Entry Name: | ZRAN1_HUMAN |
