UniProt Protein Function: | AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Other group; NAK family Chromosomal Location of Human Ortholog: 2p14 Cellular Component: clathrin-coated vesicle; cytoplasm; extrinsic to plasma membrane; leading edge; terminal button Molecular Function:Notch binding; protein binding; protein serine/threonine kinase activity Biological Process: positive regulation of Notch signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of protein localization |
NCBI Summary: | Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q2M2I8 |
NCBI GenInfo Identifier: | 300669613 |
NCBI Gene ID: | 22848 |
NCBI Accession: | Q2M2I8.3 |
UniProt Secondary Accession: | Q2M2I8,Q4ZFZ3, Q53RX6, Q9UPV4, |
UniProt Related Accession: | Q2M2I8 |
Molecular Weight: | 93,578 Da |
NCBI Full Name: | AP2-associated protein kinase 1 |
NCBI Synonym Full Names: | AP2 associated kinase 1 |
NCBI Official Symbol: | AAK1Â Â |
NCBI Protein Information: | AP2-associated protein kinase 1 |
UniProt Protein Name: | AP2-associated protein kinase 1 |
UniProt Synonym Protein Names: | Adaptor-associated kinase 1 |
Protein Family: | AP2-associated protein kinase |
UniProt Gene Name: | AAK1Â Â |
UniProt Entry Name: | AAK1_HUMAN |