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Anti-Acetyl-FOXO1-K262/K265/K274 Antibody (CAB17406)

SKU:
CAB17406
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
€139 - €419
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Description

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Antibody Name:Anti-Acetyl-FOXO1-K262/K265/K274 Antibody
Antibody SKU:CAB17406
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic acetylated peptide around K262/K265/K274 of human FOXO1.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic acetylated peptide around K262/K265/K274 of human FOXO1.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2308
Uniprot:Q12778
Cellular Location:Cytoplasm, Nucleus
Calculated MW:69kDa
Observed MW:Refer to figures
Synonyms:FKH1, FKHR, FOXO1A, FOXO1
Background:This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
UniProt Protein Function:FOXO1A: a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Oncoprotein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 13q14.1

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus

Molecular Function:beta-catenin binding; chromatin binding; protein binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding

Biological Process: anatomical structure morphogenesis; apoptosis; autophagy; blood vessel development; cell differentiation; cell glucose homeostasis; cellular response to insulin stimulus; cellular response to starvation; endocrine pancreas development; epidermal growth factor receptor signaling pathway; fat cell differentiation; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; negative regulation of apoptosis; negative regulation of fat cell differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid acetylation; response to DNA damage stimulus; thermoregulation; transcription, DNA-dependent

Disease: Rhabdomyosarcoma 2

NCBI Summary:This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
UniProt Code:Q12778
NCBI GenInfo Identifier:116241368
NCBI Gene ID:2308
NCBI Accession:Q12778.2
UniProt Secondary Accession:Q12778,O43523, Q5VYC7, Q6NSK6,
UniProt Related Accession:Q12778
Molecular Weight:
NCBI Full Name:Forkhead box protein O1
NCBI Synonym Full Names:forkhead box O1
NCBI Official Symbol:FOXO1  
NCBI Official Synonym Symbols:FKH1; FKHR; FOXO1A  
NCBI Protein Information:forkhead box protein O1
UniProt Protein Name:Forkhead box protein O1
UniProt Synonym Protein Names:Forkhead box protein O1A; Forkhead in rhabdomyosarcoma
Protein Family:Foxo1-corepressor
UniProt Gene Name:FOXO1  
UniProt Entry Name:FOXO1_HUMAN
Anti-Acetyl-FOXO1-K262/K265/K274 Antibody (CAB17406)Western blot analysis of extracts of HeLa cells, using Acetyl-FOXO1-K262/K265/K274 antibody (CAB17406) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.

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