The ADAMTS5 Monoclonal Antibody (CAB23125) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using advanced monoclonal antibody technology, specifically targets ADAMTS5 in human samples and is validated for use in a variety of research applications, including Western blotting and immunofluorescence.ADAMTS5 is known for its role in the breakdown of aggrecan, a key component of cartilage, and is implicated in the pathogenesis of osteoarthritis and other joint-related disorders. By targeting ADAMTS5 with this monoclonal antibody, researchers can gain insights into its expression patterns, activity, and potential as a therapeutic target for musculoskeletal conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
ADAMTS5 Monoclonal Antibody
SKU:
CAB23125
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Clone Number:
ARC59326
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.
Purification Method
Affinity purification
Gene ID
11096
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ADAMTS5 Rabbit mAb (CAB23125) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
