Anti-alpha smooth muscle Actin Antibody (CAB17910)

SKU:
CAB17910
€129 - €349

Description

Technical Manual

Anti-alpha smooth muscle Actin Rabbit Monoclonal Antibody

Product Name:Anti-alpha smooth muscle Actin Rabbit Monoclonal Antibody
Product SKU:CAB17910
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Immunogen:A synthesized peptide derived from human alpha smooth muscle Actin
Sequence:

Email for sequence

Gene ID:59
Swiss Prot:P62736
Synonyms:AAT6; ACTSA; MYMY5; ACTA2; actin
Calculated MW:42kDa
Observed MW:42kDa
Reactivity:Human, Mouse, Rat
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry Immunofluorescence
Positive Samples:RD, Mouse large intestine, Mouse heart, Mouse brain, Rat lung, Rat heart
Cellular Location:

Product Images

Anti-alpha smooth muscle Actin Rabbit Monoclonal Antibody (CAB17910)

Western blot - alpha smooth muscle Actin Rabbit mAb (CAB17910)

Uniprot Information

UniProt Protein Function:ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.
UniProt Protein Details:

Protein type:Contractile; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function:protein kinase binding; ATP binding

Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction

Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6

NCBI Summary:The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
UniProt Code:P62736
NCBI GenInfo Identifier:51316972
NCBI Gene ID:59
NCBI Accession:P62736.1
UniProt Secondary Accession:P62736,P03996, P04108, Q6FI19, B2R8A4,
UniProt Related Accession:P62736
Molecular Weight:42,009 Da
NCBI Full Name:Actin, aortic smooth muscle
NCBI Synonym Full Names:actin, alpha 2, smooth muscle, aorta
NCBI Official Symbol:ACTA2
NCBI Official Synonym Symbols:AAT6; ACTSA; MYMY5
NCBI Protein Information:actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
UniProt Protein Name:Actin, aortic smooth muscle
UniProt Synonym Protein Names:Alpha-actin-2; Cell growth-inhibiting gene 46 protein
Protein Family:Actin
UniProt Gene Name:ACTA2
UniProt Entry Name:ACTA_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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