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Anti-53BP1 Antibody (CAB3859)

SKU:
CAB3859
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
53BP1
TDRD30
TP53
p202
p53BP1
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

Product Name:53BP1 Rabbit mAb
Product Code:CAB3859
Size:20uL, 50uL, 100uL
Synonyms:53BP1, TDRD30, TP53, p202, p53BP1
Applications:WB, IHC, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human 53BP1
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:A synthesized peptide derived from human 53BP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7158
Uniprot:Q12888
Calculated MW:450kDa
Observed MW:450KDa
UniProt Protein Function:53BP1: a DNA damage checkpoint protein that interacts with HDAC4 protein to mediate the DNA damage response. Inhibits E2F1-mediated apoptosis in prostate cancer cells. Recruited to double strand breaks via the binding of its Tudor domain to dimethylated H3 K20. Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Binds to the central domain of p53. Interacts with Artemis. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on S139. Interacts with histone H4 that has been dimethylated at K20. Has low affinity for histone H4 containing monomethylated K20. Does not bind histone H4 containing unmethylated or trimethylated K20. Has low affinity for histone H3 that has been dimethylated on K79. Does not bind unmethylated histone H3. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Two alternatively spliced human isoforms have been observed.
UniProt Protein Details:

Protein type:DNA repair, damage; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q15-q21

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasm; replication fork; nucleus

Molecular Function:protein binding; p53 binding; damaged DNA binding; telomeric DNA binding; methylated histone residue binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; double-strand break repair; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination

UniProt Code:Q12888
NCBI GenInfo Identifier:8928568
NCBI Gene ID:7158
NCBI Accession:Q12888.2
UniProt Secondary Accession:Q12888,Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4, F8VY86,
UniProt Related Accession:Q12888
Molecular Weight:1972
NCBI Full Name:Tumor suppressor p53-binding protein 1
NCBI Synonym Full Names:tumor protein p53 binding protein 1
NCBI Official Symbol:TP53BP1  
NCBI Official Synonym Symbols:p202; 53BP1  
NCBI Protein Information:tumor suppressor p53-binding protein 1; p53BP1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1
UniProt Protein Name:Tumor suppressor p53-binding protein 1
Protein Family:Tumor suppressor p53-binding protein
UniProt Gene Name:TP53BP1  
UniProt Entry Name:TP53B_HUMAN

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