The Anti-Apolipoprotein C3 Antibody (CAB2209) is a highly specific and sensitive tool for researching apolipoprotein C3, a key protein involved in lipid metabolism and cardiovascular disease. This polyclonal antibody, generated in rabbits, is optimized for detecting apolipoprotein C3 in human samples using Western blot techniques.Apolipoprotein C3 is a crucial regulator of lipid metabolism, playing a central role in the transport and metabolism of triglycerides. Dysregulation of apolipoprotein C3 levels has been linked to a higher risk of cardiovascular disease, making it a promising target for therapeutic interventions.
This antibody enables researchers to study the expression and function of apolipoprotein C3 in various cell types and tissues, providing valuable insights into its role in lipid metabolism and disease pathology.By using the Anti-Apolipoprotein C3 Antibody (CAB2209), researchers can enhance their understanding of the molecular mechanisms underlying lipid metabolism and cardiovascular disease, ultimately paving the way for the development of novel treatments and interventions targeting apolipoprotein C3.
Product Name:
APOC3 Rabbit Monoclonal Antibody
SKU:
CAB2209
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-99 of human Apolipoprotein C3 (P02656).
early endosome, extracellular exosome, extracellular region, extracellular space
Calculated MW:
11kDa
Observed MW:
11kDa
This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
345
Clone Number:
ARC1886
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Human plasma , using Apolipoprotein C3 Rabbit mAb (CAB2209) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
