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Anti-PDZK1 Antibody (CAB8874)

SKU:
CAB8874
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CAP70
CLAMP
NHERF-3
NHERF3
PDZD1
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:PDZK1 Rabbit mAb
Product Code:CAB8874
Size:20uL, 50uL, 100uL
Synonyms:CAP70, CLAMP, NHERF-3, NHERF3, PDZD1
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PDZK1
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2
Immunogen:A synthesized peptide derived from human PDZK1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5174
Uniprot:Q5T2W1
Calculated MW:70kDa
Observed MW:70KDa
UniProt Protein Function:PDZK1: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. Belongs to the NHER family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: brush border membrane; plasma membrane

Molecular Function:PDZ domain binding; protein binding; transporter activity

Biological Process: carnitine transport; cell proliferation; transport

NCBI Summary:This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Code:Q5T2W1
NCBI GenInfo Identifier:73621372
NCBI Gene ID:5174
NCBI Accession:Q5T2W1.2
UniProt Secondary Accession:Q5T2W1,O60450, Q5T5P6, Q9BQ41, B4DPB9, E7EU02,
UniProt Related Accession:Q5T2W1
Molecular Weight:44,665 Da
NCBI Full Name:Na(+)/H(+) exchange regulatory cofactor NHE-RF3
NCBI Synonym Full Names:PDZ domain containing 1
NCBI Official Symbol:PDZK1  
NCBI Official Synonym Symbols:CAP70; CLAMP; PDZD1; NHERF3; NHERF-3  
NCBI Protein Information:Na(+)/H(+) exchange regulatory cofactor NHE-RF3
UniProt Protein Name:Na(+)/H(+) exchange regulatory cofactor NHE-RF3
UniProt Synonym Protein Names:CFTR-associated protein of 70 kDa; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3
Protein Family:PDZK1-interacting protein
UniProt Gene Name:PDZK1  
UniProt Entry Name:NHRF3_HUMAN

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