Anti-Phospho-Beclin 1-Ser15 Antibody (CABP1252)
- SKU:
- CABP1252
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ATG6
- VPS30
- beclin1
- Beclin 1
- BECN1
- beclin-1
- Research Area:
- Immunology
Description
| Product Name: | Phospho-Beclin 1-Ser15 Rabbit pAb |
| Product Code: | CABP1252 |
| Size: | 50uL, 100uL |
| Synonyms: | ATG6, VPS30, beclin1, Beclin 1, BECN1, beclin-1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Ser15 of human Beclin 1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NIH/3T3, C6 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Ser15 of human Beclin 1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8678 |
| Uniprot: | Q14457 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane |
| Calculated MW: | 52kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Autophagy; Membrane protein, peripheral Chromosomal Location of Human Ortholog: 17q21 Cellular Component: extrinsic to membrane; mitochondrion; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; phagocytic vesicle; trans-Golgi network; nucleus; endosome Molecular Function:protein binding; phosphoinositide 3-kinase binding Biological Process: response to drug; viral reproduction; late endosome to vacuole transport; cytokinesis; CVT pathway; cellular response to nitrogen starvation; negative regulation of cell proliferation; response to vitamin E; lysosome organization and biogenesis; regulation of catalytic activity; beta-amyloid metabolic process; mitochondrion degradation; response to hypoxia; cellular defense response; neuron development; defense response to virus; positive regulation of macroautophagy; positive regulation of autophagy; negative regulation of apoptosis; autophagic vacuole formation |
| NCBI Summary: | Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010] |
| UniProt Code: | Q14457 |
| NCBI GenInfo Identifier: | 4680381 |
| NCBI Gene ID: | 8678 |
| NCBI Accession: | AAD27650.1 |
| UniProt Secondary Accession: | Q14457,O75595, Q9UNA8, |
| UniProt Related Accession: | Q14457 |
| Molecular Weight: | 51,896 Da |
| NCBI Full Name: | beclin 1 |
| NCBI Synonym Full Names: | beclin 1, autophagy related |
| NCBI Official Symbol: | BECN1Â Â |
| NCBI Official Synonym Symbols: | ATG6; VPS30; beclin1Â Â |
| NCBI Protein Information: | beclin-1; ATG6 autophagy related 6 homolog; coiled-coil myosin-like BCL2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein) |
| UniProt Protein Name: | Beclin-1 |
| UniProt Synonym Protein Names: | Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 |
| Protein Family: | Beclin |
| UniProt Gene Name: | BECN1Â Â |
| UniProt Entry Name: | BECN1_HUMAN |
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