Anti-RBP4 Antibody (CAB8807)

Product Name:	RBP4 Rabbit mAb
Product Code:	CAB8807
Size:	20uL, 50uL, 100uL
Synonyms:	MCOPCB10, RDCCAS
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human RBP4

Applications:	WB, IF
Recommended Dilutions:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HepG2

Immunogen:	A synthesized peptide derived from human RBP4
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	5950
Uniprot:	P02753
Calculated MW:	23kDa
Observed MW:	22KDa

UniProt Protein Function:	Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
UniProt Protein Details:	Subcellular location: Secreted. Involvement in Disease: Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [ MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Sequence similarities: Belongs to the calycin superfamily. Lipocalin family. Mass spectrometry: Molecular mass is 21063.46±1.88 Da from positions 17 - 199. Determined by ESI. Ref.10Molecular mass is 20534 Da from positions 19 - 197. Determined by MALDI. Ref.12Molecular mass is 20162 Da from positions 19 - 194. Determined by MALDI. Ref.12 Sequence caution: The sequence AAF69622.1 differs from that shown. Reason: Erroneous initiation.
NCBI Summary:	This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq]
UniProt Code:	P02753
NCBI GenInfo Identifier:	62298174
NCBI Gene ID:	5950
NCBI Accession:	P02753.3
UniProt Secondary Accession:	P02753,O43478, O43479, Q5VY24, Q8WWA3, Q9P178, D3DR38
UniProt Related Accession:	P02753
Molecular Weight:	23,010 Da
NCBI Full Name:	Retinol-binding protein 4
NCBI Synonym Full Names:	retinol binding protein 4, plasma
NCBI Official Symbol:	RBP4
NCBI Protein Information:	retinol-binding protein 4; RBP; PRBP; OTTHUMP00000020114; OTTHUMP00000020115; OTTHUMP00000020116; plasma retinol-binding protein; retinol-binding protein 4, interstitial
UniProt Protein Name:	Retinol-binding protein 4
UniProt Synonym Protein Names:	Plasma retinol-binding protein
Protein Family:	Retinol-binding protein
UniProt Gene Name:	RBP4
UniProt Entry Name:	RET4_HUMAN