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Anti-Rhodopsin Antibody (CAB7245)

SKU:
CAB7245
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CSNBAD1
OPN2
RP4
€139 - €419
Frequently bought together:

Description

Product Name:Rhodopsin Rabbit mAb
Product Code:CAB7245
Size:20uL, 50uL, 100uL
Synonyms:CSNBAD1, OPN2, RP4
Applications:WB, IHC
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Rhodopsin
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse eye, Rat eye
Immunogen:A synthesized peptide derived from human Rhodopsin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6010
Uniprot:P08100
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:39kDa
Observed MW:28-150kDa
UniProt Protein Function:Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 3q21-q24

Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; photoreceptor inner segment; photoreceptor outer segment; plasma membrane

Molecular Function:G-protein coupled photoreceptor activity; G-protein coupled receptor activity; protein binding

Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; phototransduction, visible light; regulation of rhodopsin mediated signaling; retinoid metabolic process; rhodopsin mediated signaling

Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4

NCBI Summary:Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
UniProt Code:P08100
NCBI GenInfo Identifier:129207
NCBI Gene ID:6010
NCBI Accession:P08100.1
UniProt Secondary Accession:P08100,Q16414, Q2M249,
UniProt Related Accession:P08100
Molecular Weight:38,893 Da
NCBI Full Name:Rhodopsin
NCBI Synonym Full Names:rhodopsin
NCBI Official Symbol:RHO  
NCBI Official Synonym Symbols:RP4; OPN2; CSNBAD1  
NCBI Protein Information:rhodopsin
UniProt Protein Name:Rhodopsin
UniProt Synonym Protein Names:Opsin-2
Protein Family:Rhotekin
UniProt Gene Name:RHO  
UniProt Entry Name:OPSD_HUMAN

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