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Na+/K+-ATPase Rabbit Polyclonal Antibody (CAB12405)

SKU:
CAB12405
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Na+/K+-ATPase Rabbit Polyclonal Antibody
SKU:CAB12405
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 551-850 of human Na+/K+-ATPase (NP_000692.2).
Sequence:RVLG FCHL FLPD EQFP EGFQ FDTD DVNF PIDN LCFV GLIS MIDP PRAA VPDA VGKC RSAG IKVI MVTG DHPI TAKA IAKG VGII SEGN ETVE DIAA RLNI PVSQ VNPR DAKA CVVH GSDL KDMT SEQL DDIL KYHT EIVF ARTS PQQK LIIV EGCQ RQGA IVAV TGDG VNDS PALK KADI GVAM GIAG SDVS KQAA DMIL LDDN FASI VTGV EEGR LIFD NLKK SIAY TLTS NIPE ITPF LIFI IANI PLPL GTVT ILCI DLGT DMVP AISL AYEQ AESD IMKR QPRN PKTD KLVN ERLI
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:CMT2DD; HOMGSMR2; Na+/K+-ATPase
Positive Sample:THP-1,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Melanosome, Multi-pass membrane protein.
Calculated MW:113kDa
Observed MW:113kDa

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:476
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using Na+/K+-ATPase1 antibody (CAB12405) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.

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