The CD57 Monoclonal Antibody (HNK-1) is a specialized tool for researchers delving into the intricacies of the human immune system. This monoclonal antibody, available from Assay Genie, is engineered for high specificity and sensitivity in detecting the CD57 antigen. CD57, also referred to as HNK-1, is a marker associated with natural killer cells and a subset of T cells, providing insights into immune responses and cellular interactions.Crafted for precision, the CD57 Monoclonal Antibody (HNK-1) excels in applications such as flow cytometry, immunohistochemistry, and immunofluorescence. By targeting the CD57 antigen, researchers can elucidate the roles of natural killer cells and T cell subsets in various biological processes, including immunological surveillance, viral infections, and immune-mediated diseases.
With its robust performance and reliability, this antibody from Assay Genie empowers scientists to unravel the complexities of the human immune system with clarity and accuracy. Whether investigating immune system dysfunction in autoimmune disorders or exploring immune responses in cancer, the CD57 Monoclonal Antibody (HNK-1) is a valuable asset for advancing discoveries in immunology and beyond.
Product Title:
Purified Anti-Human CD57 Antibody [HNK-1]
SKU:
AGEL0266
Size:
25µg, 100µg
Clone No:
HNK-1
Synonyms:
HNK-1; NK-1; Leu-7;
Host Species:
Mouse
Reactivity:
Human
Application:
FCM
Isotype:
Mouse IgM, κ
Isotype Control:
Purified Mouse IgM, κ Isotype Control[MM-30]
Form:
Liquid
Conjugation:
Unconjugated
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants).
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