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Anti-CASR Antibody (CAB13000)

SKU:
CAB13000
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
€139 - €419
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Description

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Antibody Name:Anti-CASR Antibody
Antibody SKU:CAB13000
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 874-1088 of human CASR (NP_001171536.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 874-1088 of human CASR (NP_001171536.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PSRN TIEE VRCS TAAH AFKV AARA TLRR SNVS RKRS SSLG GSTG STPS SSIS SKSN SEDP FPQP ERQK QQQP LALT QQEQ QQQP LTLP QQQR SQQQ PRCK QKVI FGSG TVTF SLSF DEPQ KNAM AHRN STHQ NSLE AQKS SDTL TRHQ PLLP LQCG ETDL DLTV QETG LQGP VGGD QRPE VEDP EELS PALV VSSS QSFV ISGG GSTV TENV VNS
Gene ID:846
Uniprot:P41180
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:120kDa/121kDa
Observed MW:155kDa
Synonyms:CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR
Background:The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
UniProt Protein Function:CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 3

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:phosphoinositide phospholipase C activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; ossification

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I

NCBI Summary:The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
UniProt Code:P41180
NCBI GenInfo Identifier:1168781
NCBI Gene ID:846
NCBI Accession:P41180.2
UniProt Secondary Accession:P41180,Q13912, Q16108, Q16109, Q16110, Q16379, Q2M1T0 Q4PJ19,
UniProt Related Accession:P41180
Molecular Weight:121,772 Da
NCBI Full Name:Extracellular calcium-sensing receptor
NCBI Synonym Full Names:calcium sensing receptor
NCBI Official Symbol:CASR  
NCBI Official Synonym Symbols:CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1  
NCBI Protein Information:extracellular calcium-sensing receptor
UniProt Protein Name:Extracellular calcium-sensing receptor
UniProt Synonym Protein Names:Parathyroid cell calcium-sensing receptor 1; PCaR1
Protein Family:Extracellular calcium-sensing receptor
UniProt Gene Name:CASR  
UniProt Entry Name:CASR_HUMAN
Anti-CASR Antibody (CAB13000)Western blot analysis of extracts of rat brain, using CASR antibody (CAB13000) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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