| UniProt Protein Function: | CD93: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: cell surface; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane Molecular Function:protein binding; complement component C1q binding; receptor activity; calcium ion binding; carbohydrate binding Biological Process: macrophage activation; cell-cell adhesion; viral reproduction; phagocytosis |
| NCBI Summary: | The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NPY3 |
| NCBI GenInfo Identifier: | 21759074 |
| NCBI Gene ID: | 22918 |
| NCBI Accession: | Q9NPY3.3 |
| UniProt Secondary Accession: | Q9NPY3,O00274, |
| UniProt Related Accession: | Q9NPY3 |
| Molecular Weight: | 68,560 Da |
| NCBI Full Name: | Complement component C1q receptor |
| NCBI Synonym Full Names: | CD93 molecule |
| NCBI Official Symbol: | CD93Â Â |
| NCBI Official Synonym Symbols: | C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1Â Â |
| NCBI Protein Information: | complement component C1q receptor; C1qR; CD93 antigen; C1q receptor 1; C1q/MBL/SPA receptor; matrix-remodelling associated 4; matrix-remodeling-associated protein 4; complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1 |
| UniProt Protein Name: | Complement component C1q receptor |
| UniProt Synonym Protein Names: | C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; Complement component 1 q subcomponent receptor 1; Matrix-remodeling-associated protein 4; CD_antigen: CD93 |
| Protein Family: | Complement component C1q receptor |
| UniProt Gene Name: | CD93Â Â |
| UniProt Entry Name: | C1QR1_HUMAN |
