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CPT1A Antibody (PACO08581)

SKU:
PACO08581
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
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Description

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Antibody Name:CPT1A Antibody (PACO08581)
Antibody SKU:PACO08581
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human CPT1A
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:carnitine palmitoyltransferase 1A (liver);CPT1A;CPT1;CPT1-L;L-CPT1 ;
UniProt Protein Function:CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - fatty acid; Membrane protein, integral; EC 2.3.1.21; Mitochondrial; Membrane protein, multi-pass; Transferase

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane

Molecular Function:identical protein binding; carnitine O-palmitoyltransferase activity

Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Carnitine Palmitoyltransferase I Deficiency

NCBI Summary:The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P50416
NCBI GenInfo Identifier:56405343
NCBI Gene ID:1374
NCBI Accession:P50416.2
UniProt Secondary Accession:P50416,Q8TCU0, Q9BWK0,
UniProt Related Accession:P50416
Molecular Weight:773
NCBI Full Name:Carnitine O-palmitoyltransferase 1, liver isoform
NCBI Synonym Full Names:carnitine palmitoyltransferase 1A (liver)
NCBI Official Symbol:CPT1A  
NCBI Official Synonym Symbols:CPT1; CPT1-L; L-CPT1  
NCBI Protein Information:carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform
UniProt Protein Name:Carnitine O-palmitoyltransferase 1, liver isoform
UniProt Synonym Protein Names:Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A
Protein Family:Carnitine O-palmitoyltransferase
UniProt Gene Name:CPT1A  
UniProt Entry Name:CPT1A_HUMAN

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