Anti-CSH1 Antibody (CAB1972)

Antibody Name:	Anti-CSH1 Antibody
Antibody SKU:	CAB1972
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 27-217 of human CSH1 (NP_001308.1).

Application:	IHC
Recommended Dilution:	IHC 1:50 - 1:100
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 27-217 of human CSH1 (NP_001308.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VQTV PLSR LFDH AMLQ AHRA HQLA IDTY QEFE ETYI PKDQ KYSF LHDS QTSF CFSD SIPT PSNM EETQ QKSN LELL RISL LLIE SWLE PVRF LRSM FANN LVYD TSDS DDYH LLKD LEEG IQTL MGRL EDGS RRTG QILK QTYS KFDT NSHN HDAL LKNY GLLY CFRK DMDK VETF LRMV QCRS VEGS CGF
Gene ID:	1442
Uniprot:	P0DML2
Cellular Location:
Calculated MW:	25kDa
Observed MW:

Synonyms:

CSH1, CS-1, CSA, CSMT, GHB3, PL, hCS-1, hCS-A

Background:

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.

UniProt Protein Function:	CSH1: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Belongs to the somatotropin/prolactin family.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17q24.2 Cellular Component: extracellular region Molecular Function:hormone activity; metal ion binding
NCBI Summary:	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:	P0DML2
NCBI GenInfo Identifier:	190034
NCBI Gene ID:	1442
NCBI Accession:	AAA98621.1
UniProt Secondary Accession:	P0DML2,P01243, Q0VDB1, Q14407,
UniProt Related Accession:	P0DML2
Molecular Weight:	25,020 Da
NCBI Full Name:	placental lactogen
NCBI Synonym Full Names:	chorionic somatomammotropin hormone 1 (placental lactogen)
NCBI Official Symbol:	CSH1
NCBI Official Synonym Symbols:	PL; CSA; CS-1; CSMT; hCS-1; hCS-A
NCBI Protein Information:	chorionic somatomammotropin hormone 1; choriomammotropin; placental lactogen; chorionic somatomammotropin A; chorionic somatomammotropin-1
UniProt Protein Name:	Chorionic somatomammotropin hormone 1
UniProt Synonym Protein Names:	Lactogen; Placental lactogen; PL
UniProt Gene Name:	CSH1
UniProt Entry Name:	CSH1_HUMAN

	Immunohistochemistry of paraffin-embedded human liver using CSH1 antibody (CAB1972) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human colon carcinoma using CSH1 antibody (CAB1972) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human prostate using CSH1 antibody (CAB1972) at dilution of 1:100 (40x lens).

Antibodies	ELISA Kits
Anti-CSH1 Antibody (CAB14528)	Human PL (Pancreatic Lipase) CLIA Kit (HUES01177)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)