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[KO Validated] CYP3A4 Rabbit Polyclonal Antibody (CAB13484)

SKU:
CAB13484
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • KO Validated Antibodies 1 Anti-CYP3A4 Antibody CAB13484KO Validated
  • KO Validated Antibodies 1 Anti-CYP3A4 Antibody CAB13484KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] CYP3A4 Rabbit Polyclonal Antibody
SKU:CAB13484
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488.2).
Sequence:EVTN FLRK SVKR MKES RLED TQKH RVDF LQLM IDSQ NSKE TESH KALS DLEL VAQS IIFI FAGY ETTS SVLS FIMY ELAT HPDV QQKL QEEI DAVL PNKA PPTY DTVL QMEY LDMV VNET LRLF PIAM RLER VCKK DVEI NGMF IPKG VVVM IPSY ALHR DPKY WTEP EKFL PERF SKKN KDNI DPYI YTPF GSGP RNCI GMRF ALMN MKLA LIRV LQNF SFKP CKET QIPL KLSL GGLL QPEK PVVL KVES RDGT VSGA
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:HLP; CP33; CP34; CYP3A; NF-25; VDDR3; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; CYP3A4
Positive Sample:Rat liver
Conjugate:Unconjugated
Cellular Localization:Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein.
Calculated MW:57kDa
Observed MW:57kDa

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Purification Method:Affinity purification
Gene ID:1576
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of Rat liver, using CYP3A4 antibody (CAB13484) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.

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