Exendin 4 Recombinant Protein (RPPB1273)
- SKU:
- RPPB1273
- Product Type:
- Recombinant Protein
- Uniprot:
- P26349
- Research Area:
- Hormones
Description
| Product Name: | Exendin 4 Recombinant Protein |
| Product Code: | RPPB1273 |
| Size: | 100µg |
| Target: | Exendin 4 |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The Exendin-4 peptide was lyophilized after extensive dialyses against 20mM PBS and contains 4% mannitol. |
| Solubility: | It is recommended to reconstitute the lyophilized Exendin Recombinant in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Exendin Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Exendin-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence determined and was found to be His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser |
| Biological Activity: | 1. Regulates Glucose levels rapidly2. Reduces�GLCN.3. Reduces HbA1c4. Stimulates beta cell growth production. |
Exedin-4 Recombinant is a like peptide-1 receptor agonist. The native hormone is produced in the gut of Gila monster Heloderma suspectrum (a type of reptile found in the desert) that stimulates production without causing threateningly low blood sugar, which can occur after using some anti-diabetes products. Recently, researchers used extracted saliva from gila monsters to create an unprecedented breakthrough in Diabetes Type 2 treatment. Unlike other products taken for type 2 diabetes, Exedin-4 has not been linked with weight gain and actually resulted in weight loss, according to the researchers. Exedin-4 enhances glucose-dependant� secretion, suppresses inappropriately elevated secretion and slows gastric emptying in vivo. It also promotes B-cell proliferation and neogenesis in vitro and in animal models. Exedin-4 stimulates an increase in acinar cAMP, without stimulating the release of amylase.
Exendin-4 Recombinant is a novel 39-amino acids peptide having a molecular mass of 4186.7 Dalton, which shares 53%, sequence homology with GLP-17-36 amide and interacts with the same membrane receptor. The Exendin-4 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P26349 |
| NCBI GenInfo Identifier: | 2851623 |
| NCBI Gene ID: | |
| NCBI Accession: | P26349.2 |
| UniProt Secondary Accession: | P26349 |
| UniProt Related Accession: | P26349 |
| Molecular Weight: | |
| NCBI Full Name: | Exendin-4 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Exendin-4 |
| UniProt Synonym Protein Names: | INN: Exenatide |
| Protein Family: | |
| UniProt Gene Name: | |
| UniProt Entry Name: | EXE4_HELSU |
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