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Anti-FOXP3 Antibody (CAB17147)

SKU:
CAB17147
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€129 - €359
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Description

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Antibody Name:Anti-FOXP3 Antibody
Antibody SKU:CAB17147
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human FOXP3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human FOXP3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:50943
Uniprot:Q9BZS1
Cellular Location:Cytoplasm, Nucleus
Calculated MW:43kDa/44kDa/47kDa/49kDa
Observed MW:Refer to figures
Synonyms:FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID
Background:The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; C2H2-type zinc finger protein; DNA-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm; nucleus

Molecular Function:histone acetyltransferase binding; histone deacetylase binding; NFAT protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of cell proliferation; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of T cell anergy; response to virus; T cell activation

Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked

NCBI Summary:The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BZS1
NCBI GenInfo Identifier:14548061
NCBI Gene ID:50943
NCBI Accession:Q9BZS1.1
UniProt Secondary Accession:Q9BZS1,O60827, Q14DD8, Q4ZH51, A5HJT1, B7ZLG0, B9UN80
UniProt Related Accession:Q9BZS1
Molecular Weight:44,407 Da
NCBI Full Name:Forkhead box protein P3
NCBI Synonym Full Names:forkhead box P3
NCBI Official Symbol:FOXP3  
NCBI Official Synonym Symbols:JM2; AIID; IPEX; PIDX; XPID; DIETER  
NCBI Protein Information:forkhead box protein P3
UniProt Protein Name:Forkhead box protein P3
UniProt Synonym Protein Names:Scurfin
Protein Family:Forkhead box protein
UniProt Gene Name:FOXP3  
UniProt Entry Name:FOXP3_HUMAN

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