Anti-LGALS3 Antibody (CAB1464)
- SKU:
- CAB1464
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-LGALS3 Antibody |
| Antibody SKU: | CAB1464 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human LGALS3 (NP_002297.2). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:20 - 1:50 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human LGALS3 (NP_002297.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADN FSLH DALS GSGN PNPQ GWPG AWGN QPAG AGGY PGAS YPGA YPGQ APPG AYPG QAPP GAYP GAPG AYPG APAP GVYP GPPS GPGA YPSS GQPS ATGA YPAT GPYG APAG PLIV PYNL PLPG GVVP RMLI TILG TVKP NANR IALD FQRG NDVA FHFN PRFN ENNR RVIV CNTK LDNN WGRE ERQS VFPF ESGK PFKI QVLV EPDH FKVA VNDA HLLQ YNHR VKKL NEIS KLGI SGDI DLTS ASYT MI |
| Gene ID: | 3958 |
| Uniprot: | P17931 |
| Cellular Location: | Cytoplasm, Nucleus, Secreted |
| Calculated MW: | 26kDa |
| Observed MW: |
| Synonyms: | LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2 |
| Background: | This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | Galectin-3: galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Extracellular matrix; Cell surface Chromosomal Location of Human Ortholog: 14q22.3 Cellular Component: spliceosome; extracellular matrix; extracellular space; proteinaceous extracellular matrix; membrane; mitochondrial inner membrane; cytoplasm; plasma membrane; immunological synapse; nucleus; external side of plasma membrane Molecular Function:protein binding; laminin binding; IgE binding; carbohydrate binding; chemoattractant activity Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; RNA splicing; negative regulation of endocytosis; regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; macrophage chemotaxis; monocyte chemotaxis; epithelial cell differentiation; positive chemotaxis; eosinophil chemotaxis; innate immune response; mRNA processing; skeletal development |
| NCBI Summary: | This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014] |
| UniProt Code: | P17931 |
| NCBI GenInfo Identifier: | 215274262 |
| NCBI Gene ID: | 3958 |
| NCBI Accession: | P17931.5 |
| UniProt Secondary Accession: | P17931,Q16005, Q6IBA7, Q96J47, B2RC38, |
| UniProt Related Accession: | P17931 |
| Molecular Weight: | |
| NCBI Full Name: | Galectin-3 |
| NCBI Synonym Full Names: | lectin, galactoside-binding, soluble, 3 |
| NCBI Official Symbol: | LGALS3Â Â |
| NCBI Official Synonym Symbols: | L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2Â Â |
| NCBI Protein Information: | galectin-3; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35 |
| UniProt Protein Name: | Galectin-3 |
| UniProt Synonym Protein Names: | 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen |
| Protein Family: | Galectin |
| UniProt Gene Name: | LGALS3Â Â |
| UniProt Entry Name: | LEG3_HUMAN |
 | Immunohistochemistry of paraffin-embedded human stomach using LGALS3 Antibody (CAB1464) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using LGALS3 Antibody (CAB1464) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using LGALS3 Antibody (CAB1464) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using LGALS3 antibody (CAB1464). Blue: DAPI for nuclear staining. |
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