Description
GSTM5 Antibody (CAB15677)
The GSTM5 Antibody (CAB15677) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications.The GSTM5 protein plays a crucial role in protecting cells from oxidative stress and harmful toxins by catalyzing the conjugation of glutathione to a wide range of substrates. Dysregulation of GSTM5 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
| Product Name: | GSTM5 Antibody |
| SKU: | CAB15677 |
| Size: | 20μL, 100μL |
| Reactivity: | Mouse, Rat |
| Conjugate: | Unconjugated |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. | ||||
| Sequence: | LENQ VMDN HMEL VRLC YDPD FEKL KPKY LEEL PEKL KLYS EFLG KRPW FAGD KITF VDFL AYDV LDMK RIFE PKCL DAFL NLKD FISR FEGL KKIS AYMK SSQF LRGL LFGK SATW NSK | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | GTM5, GSTM5-5, GSTM5 |
| Positive Sample: | Mouse heart, Mouse kidney, Mouse liver, Rat testis, Rat brain |
| Cellular Localization: | Cytoplasm. |
| Calculated MW: | 26kDa |
| Observed MW: | 24-26kDa |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
| Purification Method | Affinity purification |
| Gene ID | 2949 |
| RRID | AB_2763086 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using GSTM5 Rabbit pAb (CAB15677) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3s. |
