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Anti-beta glucuronidase GUSB Antibody CAB19248
Key Features

beta glucuronidase (GUSB) Rabbit Monoclonal Antibody (CAB19248)

Datasheet MSDS
SKU CAB19248
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Rabbit
Synonyms BG, MPS7, beta glucuronidase (GUSB)
Research Use Cell Biology
€131 - €457

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Description

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beta glucuronidase (GUSB) Monoclonal Antibody (CAB19248)

The beta glucuronidase (GUSB) Monoclonal Antibody (CAB19248) is a high-quality antibody developed for reliable detection and analysis of target proteins. The antibody, produced in rabbits, has high specificity towards human samples and is validated for use in applications such as immunohistochemistry and ELISA.GUSB plays a vital role in the lysosomal degradation of glycosaminoglycans and its deficiency is associated with the rare genetic disorder, mucopolysaccharidosis. Research involving GUSB is essential for understanding the pathophysiology of diseases related to glycosaminoglycan metabolism and developing potential therapeutic interventions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:beta glucuronidase (GUSB) Monoclonal Antibody
SKU:CAB19248
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC2408
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MARG SAVA WAAL GPLL WGCA LGLQ GGML YPQE SPSR ECKE LDGL WSFR ADFS DNRR RGFE EQWY RRPL WESG PTVD MPVP SSFN DISQ DWRL RHFV GWVW
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:BG, MPS7, beta glucuronidase (GUSB)
Positive Sample:HepG2, A-549, HL-60
Cellular Localization:Lysosome.
Calculated MW:75kDa
Observed MW:75kDa

This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.

Purification MethodAffinity purification
Gene ID2990
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using beta glucuronidase (GUSB) Rabbit mAb (CAB19248) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
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