Description

PE Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The Mouse CD366 (Tim-3) Monoclonal Antibody (RMT3-23) is a PE-conjugated antibody designed for research involving Tim-3, a cell surface protein known for its role in regulating immune responses. The antibody, derived from mouse cells, is highly specific and reactive with mouse samples, validated for use in flow cytometry applications. It binds to the CD366 (Tim-3) protein, allowing for precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.CD366 (Tim-3) is an immune checkpoint molecule that plays a crucial role in immune regulation by suppressing excessive immune responses and preventing autoimmunity.

Its involvement in T cell exhaustion and tolerance makes it a promising target for research into immunotherapy and autoimmune diseases. Understanding the function of CD366 (Tim-3) is essential for developing novel therapeutic approaches that leverage its regulatory effects on immune cells in the context of cancer and chronic inflammatory conditions.

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Product Title:	PE Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:	AGEL2005
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	RMT3-23
Synonyms:	TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2a, κ
Isotype Control:	PE Rat IgG2a, κ Isotype Control[2A3]
Form:	Liquid
Conjugation:	PE
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	Q8VIM0
Gene ID:	84868
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

PE Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL2005)

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Description