UniProt Protein Function: | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
UniProt Protein Details: | |
NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q16777 |
NCBI GenInfo Identifier: | 19557656 |
NCBI Gene ID: | 8335 |
NCBI Accession: | NP_003504.2 |
UniProt Secondary Accession: | Q16777,P0C0S8, P20671, Q16777, Q6FI13, Q7L7L0, Q8IUE6 Q93077, Q96QV6, Q99878 |
UniProt Related Accession: | Q16777,P04908 |
Molecular Weight: | 14 |
NCBI Full Name: | histone H2A type 1-B/E |
NCBI Synonym Full Names: | histone cluster 1 H2A family member b |
NCBI Official Symbol: | HIST1H2ABÂ Â |
NCBI Official Synonym Symbols: | H2A/m; H2AFMÂ Â |
NCBI Protein Information: | histone H2A type 1-B/E |
UniProt Protein Name: | Histone H2A type 1-B/E |
UniProt Synonym Protein Names: | Histone H2A.2; Histone H2A/a; Histone H2A/m |
Protein Family: | Histone |
UniProt Gene Name: | HIST1H2ABÂ Â |
UniProt Entry Name: | |