The HTRA1 Polyclonal Antibody (CAB11693) is specifically designed for research involving the HTRA1 protein, a serine protease implicated in various cellular processes, including apoptosis, inflammation, and tissue remodeling. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications.HTRA1 is known to play a key role in the regulation of several signaling pathways related to cell growth and survival, making it a potential target for therapeutic interventions in cancer and neurodegenerative diseases.
By targeting HTRA1, researchers can gain insights into its mechanisms of action and potential implications for disease development and progression.Overall, the HTRA1 Polyclonal Antibody is an essential tool for studying the function and expression of the HTRA1 protein in various cell types and tissues, offering valuable insights into its roles in disease pathology and potential therapeutic targeting.
Product Name:
HTRA1 Rabbit Polyclonal Antibody
SKU:
CAB11693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-160 of human HTRA1 (NP_002766.1).
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
Purification Method:
Affinity purification
Gene ID:
5654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HTRA1 Rabbit pAb (CAB11693) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
