Human ABO Recombinant Protein (RPPB1313)
- SKU:
- RPPB1313
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P16442
- Research Area:
- Enzymes
Description
| Product Name: | Human ABO Recombinant Protein |
| Product Code: | RPPB1313 |
| Size: | 10µg |
| Species: | Human |
| Target: | ABO |
| Synonyms: | Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT, ABO, GTB, A3GALNT, A3GALT1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ABO protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 200mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAVREPDHLQ RVSLPRMVYP QPKVLTPCRK DVLVVTPWLA PIVWEGTFNI DILNEQFRLQ NTTIGLTVFA IKKYVAFLKL FLETAEKHFM VGHRVHYYVF TDQPAAVPRV TLGTGRQLSV LEVRAYKRWQ DVSMRRMEMI SDFCERRFLS EVDYLVCVDV DMEFRDHVGV EILTPLFGTL HPGFYGSSRE AFTYERRPQS QAYIPKDEGD FYYLGGFFGG SVQEVQRLTR ACHQAMMVDQ ANGIEAVWHD ESHLNKYLLR HKPTKVLSPE YLWDQQLLGW PAVLRKLRFT AVPKNHQAVR NP |
NAGAT (ABO) is a member of the glycosyltransferase 6 family. The ABO protein is the basis of the ABO blood group system and related to the first discovered blood group system, ABO. The allele that is present in an individual determines the blood group. The histo-blood group ABO is comprised of 3 carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity which converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals are deficient of such activity.
ABO Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 322 amino acids (54-354 a.a) and having a molecular mass of 37.4kDa.ABO is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ABO: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. Belongs to the glycosyltransferase 6 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.37; Membrane protein, integral; EC 2.4.1.40; Transferase Chromosomal Location of Human Ortholog: 9q34.2 Cellular Component: integral to membrane; extracellular region Molecular Function:metal ion binding; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity; fucosylgalactoside 3-alpha-galactosyltransferase activity Biological Process: protein amino acid glycosylation Disease: Blood Group, Abo System |
| NCBI Summary: | This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P16442 |
| NCBI GenInfo Identifier: | 114949 |
| NCBI Gene ID: | 28 |
| NCBI Accession: | P16442.2 |
| UniProt Related Accession: | P16442 |
| Molecular Weight: | |
| NCBI Full Name: | Histo-blood group ABO system transferase |
| NCBI Synonym Full Names: | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
| NCBI Official Symbol: | ABO�� |
| NCBI Official Synonym Symbols: | GTB; NAGAT; A3GALNT; A3GALT1�� |
| NCBI Protein Information: | histo-blood group ABO system transferase |
| UniProt Protein Name: | Histo-blood group ABO system transferase |
| UniProt Synonym Protein Names: | Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.40); Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.37); Histo-blood group A transferase; A transferase; Histo-blood group B transferase; B transferase; NAGATFucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form |
| Protein Family: | 4-methylaminobutanoate oxidase |
| UniProt Gene Name: | ABO�� |
| UniProt Entry Name: | BGAT_HUMAN |
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