Human AFP Recombinant Protein (RPPB2828)
- SKU:
- RPPB2828
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P02771
- Research Area:
- Natural Proteins
Frequently bought together:
Description
| Product Name: | Human AFP Recombinant Protein |
| Product Code: | RPPB2828 |
| Size: | 50µg |
| Species: | Human |
| Target: | AFP |
| Synonyms: | Alpha-fetoprotein, Alpha-fetoglobulin, Alpha-1-fetoprotein, AFP, FETA, HPAFP. |
| Source: | Human cord serum |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | AFP protein filtered (0.2�m) solution in Tris buffered saline pH 7.5 and less than 0.1% NaN3. |
| Stability: | Human Alpha-Fetoprotein should be stored at 2-8°C. |
AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
Human alpha-fetoprotein purified from pooled human cord serum.
| UniProt Protein Function: | AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: extracellular space; cytoplasm Molecular Function:metal ion binding Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of |
| NCBI Summary: | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02771 |
| NCBI GenInfo Identifier: | 120042 |
| NCBI Gene ID: | 174 |
| NCBI Accession: | P02771.1 |
| UniProt Secondary Accession: | P02771,B2RBU3, |
| UniProt Related Accession: | P02771 |
| Molecular Weight: | 609 |
| NCBI Full Name: | Alpha-fetoprotein |
| NCBI Synonym Full Names: | alpha-fetoprotein |
| NCBI Official Symbol: | AFP�� |
| NCBI Official Synonym Symbols: | AFPD; FETA; HPAFP�� |
| NCBI Protein Information: | alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein |
| UniProt Protein Name: | Alpha-fetoprotein |
| UniProt Synonym Protein Names: | Alpha-1-fetoprotein; Alpha-fetoglobulin |
| Protein Family: | AFP |
| UniProt Gene Name: | AFP�� |
| UniProt Entry Name: | FETA_HUMAN |
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