Human APOC1 Recombinant Protein (RPPB0049)
- SKU:
- RPPB0049
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P02654
- Research Area:
- Cytokines
Description
| Product Name: | Human APOC1 Recombinant Protein |
| Product Code: | RPPB0049 |
| Size: | 10µg |
| Species: | Human |
| Target: | APOC1 |
| Synonyms: | Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1, APOC1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | APOC1 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTPDVSSA LDKLKEFGNT LEDKARELIS RIKQSELSAK MREWFSETFQ KVKEKLKIDS |
Apolipoprotein C-I (APOC1) which expressed mainly in the liver is a part of the apolipoprotein C family. APOC1 which is usually found in plasma and responsible for the activation of esterified lechitin cholesterol takes an important part in the exchange of esterified cholesterol among lipoproteins and in removal of cholesterol from tissues. APOC1 is activated when monocytes differentiate into macrophages. APOC1 protein�s main role is to inhibit CETP by altering the electric charge of HDL molecules. APOC1 is also binds free fatty acids and reduces their intracellular esterification.
APOC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 80 amino acids (27-83 a.a.) and having a molecular mass of 9.0kDa. APOC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Lipid-binding; Secreted; Inhibitor; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: chylomicron; endoplasmic reticulum Molecular Function:phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of cholesterol transport; negative regulation of lipoprotein lipase activity; cholesterol efflux; lipoprotein metabolic process; negative regulation of receptor-mediated endocytosis; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02654 |
| NCBI GenInfo Identifier: | 114016 |
| NCBI Gene ID: | 341 |
| NCBI Accession: | P02654.1 |
| UniProt Secondary Accession: | P02654,Q6IB97, B2R526, |
| UniProt Related Accession: | P02654 |
| Molecular Weight: | 83 |
| NCBI Full Name: | Apolipoprotein C-I |
| NCBI Synonym Full Names: | apolipoprotein C-I |
| NCBI Official Symbol: | APOC1�� |
| NCBI Official Synonym Symbols: | Apo-CI; ApoC-I�� |
| NCBI Protein Information: | apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1; apolipoprotein C-I variant I |
| UniProt Protein Name: | Apolipoprotein C-I |
| UniProt Synonym Protein Names: | Apolipoprotein C1Truncated apolipoprotein C-I |
| Protein Family: | Apolipoprotein |
| UniProt Gene Name: | APOC1�� |
| UniProt Entry Name: | APOC1_HUMAN |
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