Human CD52 Recombinant Protein (RPPB3078)
- SKU:
- RPPB3078
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P31358
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD52 Recombinant Protein |
| Product Code: | RPPB3078 |
| Size: | 5µg |
| Species: | Human |
| Target: | CD52 |
| Synonyms: | CD52 Molecule, Human Epididymis-Specific Protein 5, CD52 Antigen, Epididymal Secretory Protein E5, Cambridge Pathology 1 Antigen, CDW52, He5, Epididymis Secretory Sperm Binding Protein Li 171mP, CDW52 Antigen, CD52 Antigen, HEL-S-171mP, EDDM5, CDw52, HE5. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CD52 protein solution (0.5mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GQNDTSQTSS PSLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWESNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H |
CD52 is a small GPI (glycosylphosphatidylinositol) anchored glycoprotein which is tied to the cell surface with a GPI linkage. CD52 induces immune suppression by complement-meditated cell lysis. Moreover, CD52 is expressed on lymphocytes, eosinophils, monocytes-derived dendritic cells, monocytes, as well as neutrophils, however not on the stem cells from which these lymphocytes were derived. Furthermore, CD52 is a significant goal for therapeutic interventions intended for leukocyte depletion in post-transplant immunosuppression & hematological malignancies.
CD52 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 251 amino acids (25-36 a.a.) and having a molecular mass of 28.2kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).CD52 is expressed with a 239 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | May play a role in carrying and orienting carbohydrate, as well as having a more specific role. |
| UniProt Code: | P31358 |
| NCBI GenInfo Identifier: | 399214 |
| NCBI Gene ID: | 1043 |
| NCBI Accession: | P31358.1 |
| UniProt Secondary Accession: | P31358,Q5T138, Q9BW46, |
| UniProt Related Accession: | P31358 |
| Molecular Weight: | 6,614 Da |
| NCBI Full Name: | CAMPATH-1 antigen |
| NCBI Synonym Full Names: | CD52 molecule |
| NCBI Official Symbol: | CD52�� |
| NCBI Official Synonym Symbols: | CDW52; EDDM5�� |
| NCBI Protein Information: | CAMPATH-1 antigen |
| UniProt Protein Name: | CAMPATH-1 antigen |
| UniProt Synonym Protein Names: | CDw52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5; He5; CD_antigen: CD52 |
| UniProt Gene Name: | CD52�� |
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