Human DUSP21 Recombinant Protein (RPPB1596)
- SKU:
- RPPB1596
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H596
- Research Area:
- Enzymes
Frequently bought together:
Description
| Product Name: | Human DUSP21 Recombinant Protein |
| Product Code: | RPPB1596 |
| Size: | 10µg |
| Species: | Human |
| Target: | DUSP21 |
| Synonyms: | Dual specificity phosphatase 21, Low molecular weight dual specificity phosphatase 21, LMW-DSP21, BJ-HCC-26 tumor antigen, EC 3.1.3.16, EC 3.1.3.48. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The DUSP21 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMTASAS SFSSSQGVQQ PSIYSFSQIT RSLFLSNGVA ANDKLLLSSN RITAIVNASV EVVNVFFEGI QYIKVPVTDA RDSRLYDFFD PIADLIHTID MRQGRTLLHC MAGVSRSASL CLAYLMKYHS MSLLDAHTWT KSRRPIIRPN NGFWEQLINY EFKLFNNNTV RMINSPVGNI PDIYEKDLRM MISM |
DUSP21 is a member of the protein-tyrosine phosphatase family. DUSPs inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residuesb. DUSP21 is able to dephosphorylate single and diphosphorylated synthetic MAPK peptides, favoring the phosphotyrosine and diphosphorylated forms over phosphothreonine. DUSP21 is only expressed in testis where there are dephosphorylated phosphotyrosine residues in MAPK peptides.
DUSP21 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 214 amino acids (1-190) and having a molecular mass of 24.1kDa.DUSP21 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DUSP21: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Protein type: EC 3.1.3.16; EC 3.1.3.48; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificityChromosomal Location of Human Ortholog: Xp11.4-p11.23Cellular Component: cytoplasm; mitochondrial matrix; nucleusMolecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein binding; protein tyrosine phosphatase activityBiological Process: inactivation of MAPK activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9H596 |
| NCBI GenInfo Identifier: | 225703077 |
| NCBI Gene ID: | 63904 |
| NCBI Accession: | NP_071359.3 |
| UniProt Secondary Accession: | Q9H596,Q0VDA6, Q6IAJ6, Q6YDQ8 |
| UniProt Related Accession: | Q9H596 |
| Molecular Weight: | 21,529 Da |
| NCBI Full Name: | dual specificity protein phosphatase 21 |
| NCBI Synonym Full Names: | dual specificity phosphatase 21 |
| NCBI Official Symbol: | DUSP21�� |
| NCBI Official Synonym Symbols: | LMWDSP21�� |
| NCBI Protein Information: | dual specificity protein phosphatase 21 |
| UniProt Protein Name: | Dual specificity protein phosphatase 21 |
| UniProt Synonym Protein Names: | Low molecular weight dual specificity phosphatase 21; LMW-DSP21 |
| Protein Family: | Dual specificity phosphatase |
| UniProt Gene Name: | DUSP21�� |
| UniProt Entry Name: | DUS21_HUMAN |
