Human ERP44 Recombinant Protein (RPPB3465)
- SKU:
- RPPB3465
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BS26
Description
| Product Name: | Human ERP44 Recombinant Protein |
| Product Code: | RPPB3465 |
| Size: | 25µg |
| Species: | Human |
| Target: | ERP44 |
| Synonyms: | PDIA10, TXNDC4, ER protein 44. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | 1mg/ml solution containing 20mM Tris-HCl pH-7.5 & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWAGSMEI TSLDTENIDE ILNNADVALV NFYADWCRFS QMLHPIFEEA SDVIKEEFPNENQVVFARVD CDQHSDIAQR YRISKYPTLK LFRNGMMMKR EYRGQRSVKA LADYIRQQKS DPIQEIRDLA EITTLDRSKR NIIGYFEQKDSDNYRVFERV ANILHDDCAF LSAFGDVSKP ERYSGDNIIY KPPGHSAPDM VYLGAMTNFD VTYNWIQDKC VPLVREITFE NGEELTEEGLPFLILFHMKE DTESLEIFQN EVARQLISEK GTINFLHADC DKFRHPLLHI QKTPADCPVI AIDSFRHMYV FGDFKDVLIP GKLKQFVFDLHSGKLHREFH HGPDPTDTAP GEQAQDVASS PPESSFQKLA PSEYRYTLLR DRDEL |
ERP44 is an endoplasmic reticulum chaperone that takes part in thiol-dependent retention of the primary secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. ERP44 inhibits the calcium channel activity of ITPR1. ERP44 is involved in the control of oxidative protein folding in the endoplasmic reticulum.
ERP44 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 415 amino acids (30-406 a.a.) and having a molecular mass of 48 kDa. The ERP44 is fused to a 38 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Endoplasmic reticulum; Secreted; Isomerase Chromosomal Location of Human Ortholog: 9q31.1 Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein |
| NCBI Summary: | This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q9BS26 |
| NCBI GenInfo Identifier: | 31077035 |
| NCBI Gene ID: | 23071 |
| NCBI Accession: | Q9BS26.1 |
| UniProt Related Accession: | Q9BS26 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | Endoplasmic reticulum resident protein 44 |
| NCBI Synonym Full Names: | endoplasmic reticulum protein 44 |
| NCBI Official Symbol: | ERP44�� |
| NCBI Official Synonym Symbols: | PDIA10; TXNDC4�� |
| NCBI Protein Information: | endoplasmic reticulum resident protein 44 |
| UniProt Protein Name: | Endoplasmic reticulum resident protein 44 |
| UniProt Synonym Protein Names: | Thioredoxin domain-containing protein 4 |
| Protein Family: | Endoplasmic reticulum resident protein |
| UniProt Gene Name: | ERP44�� |
| UniProt Entry Name: | ERP44_HUMAN |
