Human FGFBP Recombinant Protein (RPPB0253)
- SKU:
- RPPB0253
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q14512
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGFBP Recombinant Protein |
| Product Code: | RPPB0253 |
| Size: | 10µg |
| Species: | Human |
| Target: | FGFBP |
| Synonyms: | Fibroblast Growth Factor Binding Protein 1, FGFBP, HBP17,17 KDa Heparin-Binding Growth Factor-Binding Protein, 17 KDa HBGF-BindingProtein, FGF-Binding Protein 1, FGF-BP1, FGFBP-1, FGF-BP, Heparin-BindingGrowth Factor Binding Protein, Fibroblast Growth Factor-Binding Protein 1, Fibroblastgrowth factor-binding protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless clear solution. |
| Formulation: | FGFBP protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSKKKVKNGLHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNPTSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSPREHIKGKETT PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC |
Fibroblast Growth Factor Binding Protein 1, also known as FGFBP1 is asecreted fibroblast growth factor carrier protein. FGFBP1 plays a vital part incell proliferation, differentiation and migration by binding to fibroblastgrowth factors and potentiating their biological effects on target cells. Inaddition, FGFBP1 also takes part in tumor growth as an angiogenic switchmolecule, furthermore an expression of FGFBP1 has been associated with more than a few types of cancer as wellas pancreatic and colorectal adenocarcinoma.
FGFBP Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 234 amino acids (24-234 a.a) and having amolecular mass of 26.2kDa.FGFBP is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FGFBP1: Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Belongs to the fibroblast growth factor-binding protein family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4p15.32 Cellular Component: extracellular space; cell surface; plasma membrane Molecular Function:heparin binding; protein binding; fibroblast growth factor binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; signal transduction |
| NCBI Summary: | This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q14512 |
| NCBI GenInfo Identifier: | 74739840 |
| NCBI Gene ID: | 9982 |
| NCBI Accession: | Q14512.1 |
| UniProt Secondary Accession: | Q14512,A8K5J2, |
| UniProt Related Accession: | Q14512 |
| Molecular Weight: | 234 |
| NCBI Full Name: | Fibroblast growth factor-binding protein 1 |
| NCBI Synonym Full Names: | fibroblast growth factor binding protein 1 |
| NCBI Official Symbol: | FGFBP1�� |
| NCBI Official Synonym Symbols: | FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1�� |
| NCBI Protein Information: | fibroblast growth factor-binding protein 1; FGF-binding protein 1; 17 kDa HBGF-binding protein; heparin-binding growth factor binding protein; 17 kDa heparin-binding growth factor-binding protein |
| UniProt Protein Name: | Fibroblast growth factor-binding protein 1 |
| UniProt Synonym Protein Names: | 17 kDa heparin-binding growth factor-binding protein; 17 kDa HBGF-binding protein; HBp17 |
| Protein Family: | Fibroblast growth factor-binding protein |
| UniProt Gene Name: | FGFBP1�� |
| UniProt Entry Name: | FGFP1_HUMAN |
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