Human GDF7 Recombinant Protein (RPPB0307)
- SKU:
- RPPB0307
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q7Z4P5
- Research Area:
- Cytokines
Description
| Product Name: | Human GDF7 Recombinant Protein |
| Product Code: | RPPB0307 |
| Size: | 10µg |
| Species: | Human |
| Target: | GDF7 |
| Synonyms: | Growth Differentiation Factor 7, GDF-7, Growth/Differentiation Factor 7, BMP12, GDF7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered solution in HCl. |
| Solubility: | It is recommended to reconstitute the lyophilized GDF-7 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GDF7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-7 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR |
| Biological Activity: | The ED50, as determined by inducing alkaline phosphatase production by mouse ATDC5 cells, is less than 1.25�g/ml. |
Growth Differentiation Factor-7 (GDF-7) belongs to the BMP family of TGF-b superfamily proteins. GDF7 elicits its bioactivity via a heterodimeric receptor complex comprised of a type 1 (BMPR-IB) and a type II (BMPR-II or Activin RII) serine/threonine kinase receptor. GDF7 signaling results in the phosphorylation and activation of Smad proteins. GDF-7 is also involved in tendon and ligament formation and repair. In addition, GDF7 regulates bone formation, mesenchymal stem cell differentiation, neuronal differentiation, and axon guidance.
GDF7 Human Recombinant (322-450) produced in E.Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 28kDa.The GDF-7 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted; Secreted, signal peptide; Cell development/differentiation Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: extracellular space Molecular Function:cytokine activity; growth factor activity; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cell development; cell fate commitment; epithelial cell differentiation; forebrain morphogenesis; gland morphogenesis; growth; midbrain development; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; reproductive structure development; roof plate formation; spinal cord association neuron differentiation |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z4P5 |
| NCBI GenInfo Identifier: | 296434517 |
| NCBI Gene ID: | 151449 |
| NCBI Accession: | Q7Z4P5.2 |
| UniProt Related Accession: | Q7Z4P5 |
| Molecular Weight: | 46,950 Da |
| NCBI Full Name: | Growth/differentiation factor 7 |
| NCBI Synonym Full Names: | growth differentiation factor 7 |
| NCBI Official Symbol: | GDF7�� |
| NCBI Official Synonym Symbols: | BMP12�� |
| NCBI Protein Information: | growth/differentiation factor 7 |
| UniProt Protein Name: | Growth/differentiation factor 7 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF7�� |
| UniProt Entry Name: | GDF7_HUMAN |
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