Human GRHPR Recombinant Protein (RPPB1747)
- SKU:
- RPPB1747
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBQ7
- Research Area:
- Enzymes
Description
| Product Name: | Human GRHPR Recombinant Protein |
| Product Code: | RPPB1747 |
| Size: | 25µg |
| Species: | Human |
| Target: | GRHPR |
| Synonyms: | EC 1.1.1.79, GLXR, GLYD, GRHPR, PH2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The GRHPR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 5mM DTT and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL |
GRHPR located in the cytosol, belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. GRHPR is widely expressed in liver. GRHPR has widespread tissue expression and is involved in metabolism. GRHPR is an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities.
GRHPR Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (1-328 a.a.) and having a molecular mass of 37.8 kDa. The GRHPR is fused to a�20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GRHPR: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; Oxidoreductase; EC 1.1.1.79; EC 1.1.1.81 Chromosomal Location of Human Ortholog: 9q12 Cellular Component: peroxisomal matrix; cytoplasm; cytosol Molecular Function:glyoxylate reductase (NADP) activity; protein homodimerization activity; carboxylic acid binding; hydroxypyruvate reductase activity; NAD binding; glycerate dehydrogenase activity Biological Process: dicarboxylic acid metabolic process; glyoxylate metabolic process; metabolic process; excretion; protein oligomerization Disease: Hyperoxaluria, Primary, Type Ii |
| NCBI Summary: | This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBQ7 |
| NCBI GenInfo Identifier: | 47116943 |
| NCBI Gene ID: | 9380 |
| NCBI Accession: | Q9UBQ7.1 |
| UniProt Related Accession: | Q9UBQ7 |
| Molecular Weight: | |
| NCBI Full Name: | Glyoxylate reductase/hydroxypyruvate reductase |
| NCBI Synonym Full Names: | glyoxylate and hydroxypyruvate reductase |
| NCBI Official Symbol: | GRHPR�� |
| NCBI Official Synonym Symbols: | PH2; GLXR; GLYD�� |
| NCBI Protein Information: | glyoxylate reductase/hydroxypyruvate reductase |
| UniProt Protein Name: | Glyoxylate reductase/hydroxypyruvate reductase |
| Protein Family: | Glyoxylate reductase/hydroxypyruvate reductase |
| UniProt Gene Name: | GRHPR�� |
| UniProt Entry Name: | GRHPR_HUMAN |
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