Human HAVCR2 Recombinant Protein (RPPB5501)
- SKU:
- RPPB5501
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8TDQ0
- Research Area:
- Viral Antigens
Frequently bought together:
Description
| Product Name: | Human HAVCR2 Recombinant Protein |
| Product Code: | RPPB5501 |
| Size: | 20µg |
| Species: | Human |
| Target: | HAVCR2 |
| Synonyms: | Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell membrane protein 3, TIM-3, HAVCR2, TIM3, TIMD3, TIM3, KIM-3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The HAVCR2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSEVEY RAEVGQNAYL PCFYTPAAPG NLVPVCWGKG ACPVFECGNV VLRTDERDVN YWTSRYWLNG DFRKGDVSLT IENVTLADSG IYCCRIQIPG IMNDEKFNLK LVIKPAKVTP APTLQRDFTA AFPRMLTTRG HGPAETQTLG SLPDINLTQI STLANELRDS RLANDLRDSG ATIRIG� |
Hepatitis A Virus Cellular Receptor 2 (HAVCR2) is a member of the immunoglobulin superfamily. HACVR2 controls macrophage activation. HACVR2 inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and stimulates immunological tolerance.
Recombinant Human HAVCR2 produced in E. coli is a single polypeptide chain containing 206 amino acids (aa 22-202) and having a molecular mass of 22.7kDa.HAVCR2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: integral to membrane Disease: Rheumatoid Arthritis |
| NCBI Summary: | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q8TDQ0 |
| NCBI GenInfo Identifier: | 311033536 |
| NCBI Gene ID: | 84868 |
| NCBI Accession: | Q8TDQ0.3 |
| UniProt Related Accession: | Q8TDQ0 |
| Molecular Weight: | |
| NCBI Full Name: | Hepatitis A virus cellular receptor 2 |
| NCBI Synonym Full Names: | hepatitis A virus cellular receptor 2 |
| NCBI Official Symbol: | HAVCR2�� |
| NCBI Official Synonym Symbols: | TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2�� |
| NCBI Protein Information: | hepatitis A virus cellular receptor 2 |
| UniProt Protein Name: | Hepatitis A virus cellular receptor 2 |
| UniProt Synonym Protein Names: | T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3 |
| UniProt Gene Name: | HAVCR2�� |
| UniProt Entry Name: | HAVR2_HUMAN |
