Human HOPX Recombinant Protein (RPPB3712)
- SKU:
- RPPB3712
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BPY8
Description
| Product Name: | Human HOPX Recombinant Protein |
| Product Code: | RPPB3712 |
| Size: | 20µg |
| Species: | Human |
| Target: | HOPX |
| Synonyms: | Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1, HOPX, HOD, HOP, LAGY, NECC1, OB1, TOTO, CAMEO, SMAP31. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | HOPX protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSAETA SGPTEDQVEI LEYNFNKVDK HPDSTTLCLI AAEAGLSEEE TQKWFKQRLA KWRRSEGLPS ECRSVTD |
Homeodomain-only protein (HOPX) functions via its interaction with SRF, thus modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX inhibits SRF-dependent transcription either by hindering SRF binding to DNA or by engaging histone deacetylase (HDAC) proteins which prevent transcription by SRF. HOPX is a homeodomain protein which lacks certain conserved residues required for DNA binding. HOPX overexpression causes cardiac hypertrophy.
HOPX Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 97 amino acids (1-73 a.a) and having a molecular mass of 10.8kDa.HOPX is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HOPX: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 4q12 Cellular Component: nucleus Molecular Function:protein binding Biological Process: negative regulation of cell differentiation; regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation |
| NCBI Summary: | The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9BPY8 |
| NCBI GenInfo Identifier: | 60392394 |
| NCBI Gene ID: | 84525 |
| NCBI Accession: | Q9BPY8.1 |
| UniProt Secondary Accession: | Q9BPY8,Q8N0V6, Q96CI1, A8K0Z2, E9PB55, G3V294, |
| UniProt Related Accession: | Q9BPY8 |
| Molecular Weight: | 12,625 Da |
| NCBI Full Name: | Homeodomain-only protein |
| NCBI Synonym Full Names: | HOP homeobox |
| NCBI Official Symbol: | HOPX�� |
| NCBI Official Synonym Symbols: | HOD; HOP; OB1; LAGY; TOTO; CAMEO; NECC1; SMAP31�� |
| NCBI Protein Information: | homeodomain-only protein |
| UniProt Protein Name: | Homeodomain-only protein |
| UniProt Synonym Protein Names: | Lung cancer-associated Y protein; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1 |
| Protein Family: | Homeodomain-only protein |
| UniProt Gene Name: | HOPX�� |
| UniProt Entry Name: | HOP_HUMAN |
