ANPEP gene encodes aminopeptidase N (APN) also known as microsomal aminopeptiase, alanyl aminopeptidase, aminopeptidase M, CD13, or membrane protein p161, is a member of the peptidase M1 family. Widely expressed in many cells, tissues and species, APN cleaves the N-terminal amino acids from bioactive peptides, leading to their inactivation or degradation. Probably plays a role in regulating growth and differentiation of early B-lineage cells. It also may play a role in the catabolic pathway of the renin-angiotensin system. It degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.
Description
Background
| Information | Description |
| Product Name: | Recombinant Human APN Protein (His Tag) |
| Size: | 10µg |
| SKU: | RPES0037 |
| Activity: | |
| Synonym: | Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD13 antigen; CD13; CD13APN; PEPN; PEPNhAPN |
| Protein Construction: | Recombinant Human Aminopeptidase N is produced by our Mammalian expression system and the target gene encoding Lys69ÂLys967 is expressed with a 6His tag at the C-terminus. |
| Sequence: | Lys69ÂLys967 |
| Fusion tag: | C-6His |
| Accession: | P15144 |
| Species: | Human |
| Expressed Host: | Human Cells |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin: | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20? for 3 months. |
| Mol Mass: | 103.5 kDa |
| AP Mol Mass: | 110-130 kDa |
| Formulation: | Supplied as a 0.2 uM filtered solution of PBS, pH 7.4. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
