Human IL 22 Recombinant Protein (RPPB0637)
- SKU:
- RPPB0637
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9GZX6
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 22 Recombinant Protein |
| Product Code: | RPPB0637 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL 22 |
| Synonyms: | IL-TIF, TIFa, IL-10-related T-cell-derived-inducible factor, IL-22, ILTIF, IL-D110, zcyto18, MGC79382, MGC79384, TIFIL-23. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Each mg contains 50mM Phosphate buffer pH=7.1. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-22 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL22 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Ile-Ser |
| Biological Activity: | The Biological Activity was determined by the ability to activiate STAT following receptor ligand interaction. |
IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Interleukin-22 Human Recombinant produced in E.Coli is a single, non-glycosylated homodimeric polypeptide chain containing 2 x 146 amino acids and having a total molecular mass of 33,607 Dalton. The IL-22 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 12q15 Cellular Component: extracellular space; extracellular region Molecular Function:interleukin-22 receptor binding; cytokine activity Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response |
| UniProt Code: | Q9GZX6 |
| NCBI GenInfo Identifier: | 17366814 |
| NCBI Gene ID: | 50616 |
| NCBI Accession: | Q9GZX6.1 |
| UniProt Related Accession: | Q9GZX6 |
| Molecular Weight: | Calculated MW: 20kDaObserved MW: Refer to figures |
| NCBI Full Name: | Interleukin-22 |
| NCBI Synonym Full Names: | interleukin 22 |
| NCBI Official Symbol: | IL22�� |
| NCBI Official Synonym Symbols: | TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23�� |
| NCBI Protein Information: | interleukin-22; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor |
| UniProt Protein Name: | Interleukin-22 |
| UniProt Synonym Protein Names: | Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL22�� |
| UniProt Entry Name: | IL22_HUMAN |
