Human IL4R Recombinant Protein (RPPB0514)
- SKU:
- RPPB0514
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P24394
- Research Area:
- Cytokines
Description
| Product Name: | Human IL4R Recombinant Protein |
| Product Code: | RPPB0514 |
| Size: | 15µg |
| Species: | Human |
| Target: | IL4R |
| Synonyms: | Interleukin 4 Receptor, IL-4 Receptor Subunit Alpha, Interleukin 13 Receptor, IL-4RA, IL4RA, Interleukin-4 Receptor Subunit Alpha, Interleukin-4 Receptor Alpha Chain, IL4R Nirs Variant 1, IL-4R Subunit Alpha, CD124 Antigen, IL-4R-Alpha, CD124, IL4R. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL4R protein solution (0.25mg/ml) contains Phosphate buffered saline (pH7.4).� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKVLQEPTCV SDYMSISTCE WKMNGPTNCS TELRLLYQLV FLLSEAHTCI PENNGGAGCV CHLLMDDVVS ADNYTLDLWA GQQLLWKGSF KPSEHVKPRA PGNLTVHTNV SDTLLLTWSN PYPPDNYLYN HLTYAVNIWS ENDPADFRIY NVTYLEPSLR IAASTLKSGI SYRARVRAWAQCYNTTWSEW SPSTKWHNSY REPFEQHLEH HHHHH |
IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
IL4R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (26-232 a.a.) and fused to an 8 aa His Tag at C-terminus containing a total of 215 amino acids and having a molecular mass of 24.7kDa.IL4R shows multiple bands between 28-40kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. |
| NCBI Summary: | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P24394 |
| NCBI GenInfo Identifier: | 124335 |
| NCBI Gene ID: | 3566 |
| NCBI Accession: | P24394.1 |
| UniProt Secondary Accession: | P24394,Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185 Q9H186, Q9H187, B4E076, B9EKU8, H3BSY5, |
| UniProt Related Accession: | P24394 |
| Molecular Weight: | 88,267 Da |
| NCBI Full Name: | Interleukin-4 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 4 receptor |
| NCBI Official Symbol: | IL4R�� |
| NCBI Official Synonym Symbols: | CD124; IL4RA; IL-4RA�� |
| NCBI Protein Information: | interleukin-4 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-4 receptor subunit alpha |
| UniProt Synonym Protein Names: | CD_antigen: CD124 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL4R�� |
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