Human PI3 Recombinant Protein (RPPB4246)
- SKU:
- RPPB4246
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P19957
Description
| Product Name: | Human PI3 Recombinant Protein |
| Product Code: | RPPB4246 |
| Size: | 10µg |
| Species: | Human |
| Target: | PI3 |
| Synonyms: | Elafin, ESI, SKALP, WAP3, WFDC14. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PI3 solution (0.2mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | AVTGVPVKGQ DTVKGRVPFN GQDPVKGQVS VKGQDKVKAQ EPVKGPVSTK PGSCPIILIR CAMLNPPNRC LKDTDCPGIK KCCEGSCGMA CFVPQHHHHH H |
Peptidase Inhibitor 3, also referred to PI3, is neutrophil and pancreatic elastase-specific inhibitor of skin. The protein may prevent elastase mediated tissue proteolysis. PI3 has shown inhibition of alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor, a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1.
PI3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 101 amino acids (23-117a.a) and having a molecular mass of 10.7kDa.PI3 is fused to an 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | elafin: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Inhibitor; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: proteinaceous extracellular matrix Molecular Function:serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: copulation |
| NCBI Summary: | This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P19957 |
| NCBI GenInfo Identifier: | 119262 |
| NCBI Gene ID: | 5266 |
| NCBI Accession: | P19957.3 |
| UniProt Secondary Accession: | P19957,Q6FG74, E1P618, |
| UniProt Related Accession: | P19957 |
| Molecular Weight: | 12,270 Da |
| NCBI Full Name: | Elafin |
| NCBI Synonym Full Names: | peptidase inhibitor 3, skin-derived |
| NCBI Official Symbol: | PI3�� |
| NCBI Official Synonym Symbols: | ESI; WAP3; SKALP; WFDC14; cementoin�� |
| NCBI Protein Information: | elafin; PI-3; trappin-2; pre-elafin; protease inhibitor WAP3; elastase-specific inhibitor; skin-derived antileukoproteinase; WAP four-disulfide core domain 14; WAP four-disulfide core domain protein 14; protease inhibitor 3, skin-derived (SKALP) |
| UniProt Protein Name: | Elafin |
| UniProt Synonym Protein Names: | Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14 |
| Protein Family: | Elafin |
| UniProt Gene Name: | PI3�� |
| UniProt Entry Name: | ELAF_HUMAN |
