Human PIP4K2B Recombinant Protein (RPPB2611)
- SKU:
- RPPB2611
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P78356
- Research Area:
- Enzymes
Description
| Product Name: | Human PIP4K2B Recombinant Protein |
| Product Code: | RPPB2611 |
| Size: | 10µg |
| Species: | Human |
| Target: | PIP4K2B |
| Synonyms: | PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, Diphosphoinositide kinase 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type II beta, PI(5)P 4-kinase type II beta, PIP4KII-beta, PtdIns(5)P-4-kinase isoform 2-beta, PIP4K2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PIP4K2B protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSNCTS TTAVAVAPLS ASKTKTKKKH FVCQKVKLFR ASEPILSVLM WGVNHTINEL SNVPVPVMLM PDDFKAYSKI KVDNHLFNKE NLPSRFKFKE YCPMVFRNLR ERFGIDDQDY QNSVTRSAPI NSDSQGRCGT RFLTTYDRRF VIKTVSSEDV AEMHNILKKY HQFIVECHGN TLLPQFLGMY RLTVDGVETY MVVTRNVFSH RLTVHRKYDL KGSTVAREAS DKEKAKDLPT FKDNDFLNEG QKLHVGEESK KNFLEKLKRD VEFLAQLKIM DYSLLVGIHD VDRAEQEEME VEERAEDEEC ENDGVGGNLL CSYGTPPDSP GNLLSFPRFF GPGEFDPSVD VYAMKSHESS PKKEVYFMAI IDILTPYDTK KKAAHAAKTV KHGAGAEIST VNPEQYSKRF NEFMSNILT |
Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta (PIP4K2B) belongs to the phosphatidylinositol-4-phosphate 5-kinase family.PIP4K2B catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the 5th hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. PIP4K2B amino acid sequence does not show resemblance to another kinases although PIP4K2B presents kinase activity.PIP4K2B also interacts with p55 TNF receptor.
PIP4K2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 439 amino acids (1-416 a.a) and having a molecular mass of 49.8kDa.PIP4K2B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PIP4K2B: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: autophagic vacuole; cytosol; nucleoplasm Molecular Function:1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein binding; protein homodimerization activity; receptor signaling protein activity Biological Process: cell surface receptor linked signal transduction; phosphatidylinositol biosynthetic process; phospholipid metabolic process; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade |
| NCBI Summary: | The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78356 |
| NCBI GenInfo Identifier: | 47605991 |
| NCBI Gene ID: | 8396 |
| NCBI Accession: | P78356.1 |
| UniProt Secondary Accession: | P78356,Q5U0E8, Q8TBP2, |
| UniProt Related Accession: | P78356 |
| Molecular Weight: | Calculated MW: 32kDa/47kDaObserved MW: 47kDa |
| NCBI Full Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
| NCBI Synonym Full Names: | phosphatidylinositol-5-phosphate 4-kinase type 2 beta |
| NCBI Official Symbol: | PIP4K2B�� |
| NCBI Official Synonym Symbols: | PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta�� |
| NCBI Protein Information: | phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
| UniProt Protein Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
| UniProt Synonym Protein Names: | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta |
| Protein Family: | Phosphatidylinositol 5-phosphate 4-kinase |
| UniProt Gene Name: | PIP4K2B�� |
