Human PPIL1 Recombinant Protein (RPPB2154)
- SKU:
- RPPB2154
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y3C6
- Research Area:
- Enzymes
Description
| Product Name: | Human PPIL1 Recombinant Protein |
| Product Code: | RPPB2154 |
| Size: | 50µg |
| Species: | Human |
| Target: | PPIL1 |
| Synonyms: | Peptidyl-Prolyl Cis-Trans Isomerase-Like 1, PPIL-1, CYPL1, hCyPX, MGC678, PPIase, CGI-124, PPIL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | PPIL1 solution containing 20 mM Tris-HCl buffer (pH 8.0) and 20% glycerol |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSGLEHH HHHH |
| Biological Activity: | Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. |
PPIL1 belongs to the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a well conserved, ubiquitous family, members of which take an significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 protein increases the folding of proteins and catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of stathmin. PPIL1 is a novel molecular target for colon-cancer therapy.
PPIL1 Human Recombinant protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 174 amino acids (1-166) and having a molecular mass of 19.3 kDa. PPIL1 is fused to 8 amino acid His Tag at C-terminus and is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPIL1: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; Spliceosome; EC 5.2.1.8; Cyclophilin Chromosomal Location of Human Ortholog: 6p21.1 Molecular Function:peptidyl-prolyl cis-trans isomerase activity; protein binding Biological Process: nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3C6 |
| NCBI GenInfo Identifier: | 20177874 |
| NCBI Gene ID: | 51645 |
| NCBI Accession: | Q9Y3C6.1 |
| UniProt Secondary Accession: | Q9Y3C6,O15001, Q5TDC9, |
| UniProt Related Accession: | Q9Y3C6 |
| Molecular Weight: | 18,237 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase-like 1 |
| NCBI Synonym Full Names: | peptidylprolyl isomerase like 1 |
| NCBI Official Symbol: | PPIL1�� |
| NCBI Official Synonym Symbols: | CYPL1; hCyPX; PPIase; CGI-124�� |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase-like 1 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase-like 1 |
| UniProt Synonym Protein Names: | Rotamase PPIL1 |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIL1�� |
| UniProt Entry Name: | PPIL1_HUMAN |
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