Human RNLS Recombinant Protein (RPPB2252)
- SKU:
- RPPB2252
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q5VYX0
- Research Area:
- Enzymes
Description
| Product Name: | Human RNLS Recombinant Protein |
| Product Code: | RPPB2252 |
| Size: | 20µg |
| Species: | Human |
| Target: | RNLS |
| Synonyms: | Renalase FAD-Dependent Amine Oxidase, Chromosome 10 Open Reading Frame 59, Monoamine Oxidase-C, C10orf59, FLJ11218, Renalase, MAO-C, EC 1.4.-.-. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RNLS solution contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMALLRRQ TSGPLYLAVW DKAEDSGGRM TTACSPHNPQ CTADLGAQYI TCTPHYAKKH QRFYDELLAY GVLRPLSSPI EGMVMKEGDC NFVAPQGISS IIKHYLKESG AEVYFRHRVT QINLRDDKWE VSKQTGSPEQ FDLIVLTMPV PEILQLQGDI TTLISECQRQ QLEAVSYSSR YALGLFYEAG TKIDVPWAGQ YITSNPCIRF VSIDNKKRNI ESSEIGPSLV IHTTVPFGVT YLEHSIEDVQ ELVFQQLENI LPGLPQPIAT KCQKWRHSQV TNAAANCPGQ MTLHHKPFLA CGGDGFTQSN FDGCITSALC VLEALKNYI |
Renalase (RNLS) is a flavin adenine dinucleotide-dependent amine oxidase which is secreted into the blood from the kidney. RNLS acts as a hormone which metabolizes circulating catecholamines that have an active role in the sympathetic and parasympathetic nervous systems. High catecholamine concentration activates plasma RNLS and promotes its secretion and synthesis.
RNLS Human Recombinant produced in E. coli is a single polypeptide chain containing 349 amino acids (18-342) and having a molecular mass of 38.8 kDa.RNLS is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Secreted, signal peptide; Secreted; EC 1.6.3.5 Chromosomal Location of Human Ortholog: 10q23.31 Cellular Component: extracellular space Molecular Function:oxidoreductase activity Biological Process: heart contraction; regulation of systemic arterial blood pressure; epinephrine metabolic process; phosphate ion homeostasis; norepinephrine metabolic process; dopamine metabolic process |
| NCBI Summary: | Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q5VYX0 |
| NCBI GenInfo Identifier: | 73914006 |
| NCBI Gene ID: | 55328 |
| NCBI Accession: | Q5VYX0.1 |
| UniProt Secondary Accession: | Q5VYX0,Q9BS33, Q9NUP8, |
| UniProt Related Accession: | Q5VYX0 |
| Molecular Weight: | 34,949 Da |
| NCBI Full Name: | Renalase |
| NCBI Synonym Full Names: | renalase, FAD-dependent amine oxidase |
| NCBI Official Symbol: | RNLS�� |
| NCBI Official Synonym Symbols: | C10orf59; RENALASE�� |
| NCBI Protein Information: | renalase; MAO-C; alpha-NAD(P)H oxidase/anomerase; monoamine oxidase-C |
| UniProt Protein Name: | Renalase |
| UniProt Synonym Protein Names: | Monoamine oxidase-C; MAO-C; alpha-NAD(P)H oxidase/anomerase |
| UniProt Gene Name: | RNLS�� |
| UniProt Entry Name: | RNLS_HUMAN |
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