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Human TARS Recombinant Protein (RPPB2306)

SKU:
RPPB2306
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P26639
Research Area:
Enzymes
€273
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Description

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Product Name:Human TARS Recombinant Protein
Product Code:RPPB2306
Size:20µg
Species:Human
Target:TARS
Synonyms:Threonyl-tRNA synthetase cytoplasmic, EC 6.1.1.3, Threonine-tRNA ligase, ThrRS, MGC9344, PL-7, TARS.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:TARS is supplied in 20mM HEPES buffer pH-8, 200mM sodium chloride, and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles.
Purity:TARS purity is greater than 90% as determined by SDS-PAGE.

Threonyl-tRNA Synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases.

TARS�Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 83,312 Dalton. TARS is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.

UniProt Protein Function:TARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:EC 6.1.1.3; Translation; Ligase

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: cytoplasm; cytosol; actin cytoskeleton

Molecular Function:threonine-tRNA ligase activity; protein homodimerization activity; ATP binding

Biological Process: tRNA aminoacylation for protein translation; translation; threonyl-tRNA aminoacylation; gene expression

NCBI Summary:Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
UniProt Code:P26639
NCBI GenInfo Identifier:60267755
NCBI Gene ID:6897
NCBI Accession:P26639.3
UniProt Related Accession:P26639
Molecular Weight:~ 83kDa
NCBI Full Name:Threonine--tRNA ligase 1, cytoplasmic
NCBI Synonym Full Names:threonyl-tRNA synthetase 1
NCBI Official Symbol:TARS1��
NCBI Official Synonym Symbols:TARS; TTD7; ThrRS��
NCBI Protein Information:threonine--tRNA ligase 1, cytoplasmic
UniProt Protein Name:Threonine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names:Threonyl-tRNA synthetase; ThrRS
UniProt Gene Name:TARS��
UniProt Entry Name:SYTC_HUMAN

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