Human UBE2R2 Recombinant Protein (RPPB2389)
- SKU:
- RPPB2389
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q712K3
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2R2 Recombinant Protein |
| Product Code: | RPPB2389 |
| Size: | 10µg |
| Species: | Human |
| Target: | UBE2R2 |
| Synonyms: | CDC34B, E2-CDC34B, UBC3B, Ubiquitin carrier protein R2, Ubiquitin-conjugatingenzyme E2-CDC34B, Ubiquitin-protein ligase R2, Ubiquitin-conjugating enzyme E2R2, EC 6.3.2.19. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | UBE2R2 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAQQQMT SSQKALMLEL KSLQEEPVEG FRITLVDESD LYNWEVAIFGPPNTLYEGGY FKAHIKFPID YPYSPPTFRF LTKMWHPNIY ENGDVCISIL HPPVDDPQSG ELPSERWNPTQNVRTILLSV ISLLNEPNTF SPANVDASVM FRKWRDSKGK DKEYAEIIRK QVSATKAEAE KDGVKVPTTL AEYCIKTKVP SNDNSSDLLYDDLYDDDIDD EDEEEEDADC YDDDDSGNEE S |
Ubiquitin-conjugatingenzyme E2 R2 (UBE2R2) is a member of the ubiquitin-conjugatingenzyme family. Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thrprotein kinase implicated in cell growth and transformation. This protein is a protein similar to theE2 ubiquitin conjugating enzymeUBC3/CDC34. Studies proposethat CK2-dependent phosphorylation of this ubiquitin-conjugating enzymefunctions by regulating beta-TrCPsubstrate recognition and induces itsinteraction with beta-TrCP, enhancing beta-catenin degradation. UBE2R2 receives ubiquitin from the E1complex and catalyzes its covalent attachment to other proteins. In vitro catalyzesmonoubiquitination and 'Lys-48'-linked polyubiquitination. UBE2R2 may be implicatedin degradation of katenin. Among the diseases associated with UBE2R2 are cblc,and herpes simplex.
UBE2R2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 261 amino acids (1-238 a.a) and having a molecular mass of 29.6kDa (Molecular size on SDS-PAGE will appear higher).UBE2R2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBC3B: an E2 ubiquitin conjugating enzyme similar to UBC3/CDC34. Phosphorylation of UBC3B by CK2 induces its interaction with beta-TrCP, regulating beta-TrCP substrate recognition and enhancing beta-catenin degradation. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: cytoplasm Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process |
| NCBI Summary: | Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q712K3 |
| NCBI GenInfo Identifier: | 74749761 |
| NCBI Gene ID: | 54926 |
| NCBI Accession: | Q712K3.1 |
| UniProt Secondary Accession: | Q712K3,Q9NX64, D3DRL5, |
| UniProt Related Accession: | Q712K3 |
| Molecular Weight: | 238 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 R2 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2R 2 |
| NCBI Official Symbol: | UBE2R2�� |
| NCBI Official Synonym Symbols: | UBC3B; CDC34B; E2-CDC34B�� |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 R2; ubiquitin-protein ligase R2; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme UBC3B; ubiquitin-conjugating enzyme E2-CDC34B |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 R2 |
| UniProt Synonym Protein Names: | Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2 |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2R2�� |
| UniProt Entry Name: | UB2R2_HUMAN |
