Human UBE2V2 Recombinant Protein (RPPB5828)
- SKU:
- RPPB5828
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15819
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2V2 Recombinant Protein |
| Product Code: | RPPB5828 |
| Size: | 20µg |
| Species: | Human |
| Target: | UBE2V2 |
| Synonyms: | DDVit-1, DDVIT1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2, Ubiquitin-conjugating enzyme E2 variant 2, Enterocyte differentiation-associated factor 1, Enterocyte differentiation-promoting factor 1, Vitamin D3-inducible protein, UBE2V2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | UBE2V2 Human solution containing 20mM Tris pH-8, 0.1M NaCl & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN |
UBE2V2 comprises a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes however require the conserved cysteine residue that is vital for the catalytic activity of E2s. UBE2V2 shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. UBE2V2 participates in the differentiation of monocytes and enterocytes.
UBE2V2 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-145 a.a.) and having a molecular mass of 18.5 kDa. The UBE2V2 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBE2V2: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Belongs to the ubiquitin-conjugating enzyme family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8q11.21 Cellular Component: cytoplasm; nucleus; UBC13-MMS2 complex Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding Biological Process: regulation of DNA repair; positive regulation of synaptogenesis; cell proliferation; protein polyubiquitination; positive regulation of DNA repair; postreplication repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; DNA double-strand break processing; protein ubiquitination; negative regulation of neuron apoptosis |
| NCBI Summary: | Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15819 |
| NCBI GenInfo Identifier: | 51701935 |
| NCBI Gene ID: | 7336 |
| NCBI Accession: | Q15819.4 |
| UniProt Related Accession: | Q15819 |
| Molecular Weight: | 145 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 variant 2 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2 variant 2 |
| NCBI Official Symbol: | UBE2V2�� |
| NCBI Official Synonym Symbols: | MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1�� |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 variant 2; DDVit 1; MMS2 homolog; vitamin D3-inducible protein; 1 alpha,25-dihydroxyvitamin D3-inducible; enterocyte differentiation promoting factor; enterocyte differentiation-promoting factor 1; enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 variant 2 |
| UniProt Synonym Protein Names: | DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2V2�� |
| UniProt Entry Name: | UB2V2_HUMAN |
