Human UBE2Z Recombinant Protein (RPPB2394)
- SKU:
- RPPB2394
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H832
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2Z Recombinant Protein |
| Product Code: | RPPB2394 |
| Size: | 10µg |
| Species: | Human |
| Target: | UBE2Z |
| Synonyms: | HOYS7, USE1, Ubiquitin-conjugating enzyme E2 Z, E2 ubiquitin-conjugating enzyme Z, Uba6-specific E2 conjugating enzyme 1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, UBE2Z. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The UBE2Z solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSIYKEP PPGMFVVPDT VDMTKIHALI TGPFDTPYEG GFFLFVFRCP PDYPIHPPRV KLMTTGNNTV RFNPNFYRNG KVCLSILGTW TGPAWSPAQS ISSVLISIQS LMTENPYHNE PGFEQERHPG DSKNYNECIR HETIRVAVCD MMEGKCPCPE PLRGVMEKSF LEYYDFYEVA CKDRLHLQGQ TMQDPFGEKR GHFDYQSLLM RLGLIRQKVL ERLHNENAEM DSDSSSSGTE TDLHGSLRV |
Ubiquitin Conjugating Enzyme E2Z, also known as UBE2z, is a protein coding gene which is a part of the ubiquitin-conjugating enzyme family. UBE2z catalyzes the covalent attachment of ubiquitin to various proteins. UBE2z takes part in in apoptosis regulation and is also a specific substrate for UBA6, not charged with ubiquitin by UBE1.
UBE2Z Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 269 amino acids (1-246a.a) and having a molecular mass of 30.5kDa. UBE2Z is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBE2Z: Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: cytoplasm; nucleoplasm Molecular Function:ATP binding; protein binding; ubiquitin protein ligase binding Biological Process: apoptosis; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9H832 |
| NCBI GenInfo Identifier: | 134035344 |
| NCBI Gene ID: | 65264 |
| NCBI Accession: | Q9H832.2 |
| UniProt Secondary Accession: | Q9H832,Q7L354, Q8TCM4, Q9H893, A6N8M6, A6NC60, |
| UniProt Related Accession: | Q9H832 |
| Molecular Weight: | 28,075 Da |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 Z |
| NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 Z |
| NCBI Official Symbol: | UBE2Z�� |
| NCBI Official Synonym Symbols: | USE1; HOYS7�� |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 Z |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 Z |
| UniProt Synonym Protein Names: | E2 ubiquitin-conjugating enzyme Z; Uba6-specific E2 conjugating enzyme 1; Use1; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z |
| Protein Family: | Protein transport protein |
| UniProt Gene Name: | UBE2Z�� |
| UniProt Entry Name: | UBE2Z_HUMAN |
