Human UGT8 Recombinant Protein (RPPB2402)
- SKU:
- RPPB2402
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16880
- Research Area:
- Enzymes
Description
| Product Name: | Human UGT8 Recombinant Protein |
| Product Code: | RPPB2402 |
| Size: | 20µg |
| Species: | Human |
| Target: | UGT8 |
| Synonyms: | UDPGlycosyltransferase 8, CGT, UDP-Galactose Ceramide Galactosyltransferase, 2-Hydroxyacylsphingosine1-Beta-Galactosyltransferase, Ceramide UDP-Galactosyltransferase, Cerebroside Synthase,UGT4, UDP-Galactose-Ceramide Galactosyltransferase, Uridine DiphosphateGlycosyltransferase 8, EC 2.4.1.45, EC 2.4.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | UGT8 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSAKIIIVP PIMFESHMYI FKTLASALHE RGHHTVFLLS EGRDIAPSNH YSLQRYPGIF NSTTSDAFLQ SKMRNIFSGR LTAIELFDIL DHYTKNCDLM VGNHALIQGL KKEKFDLLLV DPNDMCGFVI AHLLGVKYAV FSTGLWYPAE VGAPAPLAYV PEFNSLLTDR MNLLQRMKNT GVYLISRLGV SFLVLPKYER IMQKYNLLPE KSMYDLVHGS SLWMLCTDVA LEFPRPTLPN VVYVGGILTK PASPLPEDLQ RWVNGANEHG FVLVSFGAGV KYLSEDIANK LAGALGRLPQ KVIWRFSGPK PKNLGNNTKL IEWLPQNDLL GHSKIKAFLS HGGLNSIFET MYHGVPVVGI PLFGDHYDTM TRVQAKGMGI LLEWKTVTEK ELYEALVKVI NNPSYRQRAQ KLSEIHKDQP GHPVNRTIYW IDYIIRHNGA HHLRAAVHQI SFCQYFLLDI AFVLLLGAAL LYFLLSWVTK FIYRKIKSLW SRNKHSTVNG HYHNGILNGK YKRNGHIKHE KKVK |
UDP Glycosyltransferase 8 (UGT8) is a member of the UDP-glycosyltransferase family. UGT8 catalyzes the transfer of galactose to ceramide, a crucial enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
UGT8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 544 amino acids (21-541 a.a) and having a molecular mass of 61.6kDa.UGT8 is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | UGT8: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Belongs to the UDP-glycosyltransferase family. |
| UniProt Protein Details: | Protein type:Transferase; Lipid Metabolism - sphingolipid; EC 2.4.1.45; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q26 Cellular Component: intracellular membrane-bound organelle; integral to membrane Molecular Function:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity; glucuronosyltransferase activity; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Biological Process: central nervous system development; flavonoid biosynthetic process; galactosylceramide biosynthetic process; axon cargo transport; cytoskeleton organization and biogenesis; neurite morphogenesis; cellular response to hormone stimulus; peripheral nervous system development; paranodal junction assembly |
| NCBI Summary: | The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q16880 |
| NCBI GenInfo Identifier: | 189491660 |
| NCBI Gene ID: | 7368 |
| NCBI Accession: | NP_001121646.1 |
| UniProt Secondary Accession: | Q16880,O00196, B3KXU7, |
| UniProt Related Accession: | Q16880 |
| Molecular Weight: | 61,438 Da |
| NCBI Full Name: | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
| NCBI Synonym Full Names: | UDP glycosyltransferase 8 |
| NCBI Official Symbol: | UGT8�� |
| NCBI Official Synonym Symbols: | CGT; UGT4�� |
| NCBI Protein Information: | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; ceramide UDP-galactosyltransferase; cerebroside synthase; uridine diphosphate glycosyltransferase 8 |
| UniProt Protein Name: | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
| UniProt Synonym Protein Names: | Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase |
| Protein Family: | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
| UniProt Gene Name: | UGT8�� |
| UniProt Entry Name: | CGT_HUMAN |
